PDF(Pubmed)
Abstract：
Introduction: Numerous strategies have been investigated for addressing recurrent implantation failure (RIF) and enhancing endometrial receptivity, yet agreement on the optimal intervention remains elusive. Our investigation endeavors to assess the effect of low-level laser therapy (LLLT) on pregnancy outcomes in individuals who have undergone a minimum of three unsuccessful embryo transfer cycles (ET). Methods: In our randomized single-blinded clinical trial, we enrolled thirty females with a medical history of RIF who were eligible for frozen-thawed embryo transfer (FET). Through a random allocation sequence, the participants were divided into two groups. The LLLT was performed one cycle before blastocyst transfer in 15 cases using a New Age BIOLASER device (New Age Co., Italy) with a 900-milliwatt power output and an 850-nm wavelength. The irradiation sessions were conducted transabdominal on the hypogastric area. The considered outcomes were biochemical pregnancy, identified by a positive blood pregnancy test, and clinical pregnancy, confirmed through visualization of the gestational sac using ultrasonography. Results: The mean age of the subjects was 34.17 years, and they had undergone three to seven previous embryo transfers. There was no significant difference in basic characteristics between the group undergoing laser treatment and the control group. However, the laser-treated group exhibited elevated rates of both biochemical and clinical pregnancies compared to the control group (46.7% vs. 33.3%; P==0.710 and 33.3% vs. 20.0%; P=0.682 respectively). Conclusion: To our knowledge, this study represents the first single-blinded randomized clinical trial to assess the effectiveness of LLLT pretreatment in individuals with RIF. The findings propose that LLLT may potentially enhance biochemical and clinical pregnancy rates among RIF patients.
摘要：
简介：已经研究了许多策略来解决复发性植入失败（RIF）和增强子宫内膜容受性。然而，就最佳干预措施达成一致仍然遥不可及。我们的调查努力评估低水平激光治疗（LLLT）对经历了至少三个不成功的胚胎移植周期（ET）的个体的妊娠结局的影响。方法：在我们的随机单盲临床试验中，我们纳入了30名具有RIF病史的女性,她们符合冻融胚胎移植(FET)的条件.通过随机分配序列，参与者分为两组。使用NewAgeBIOLASER装置（NewAgeCo.，意大利）具有900毫瓦的功率输出和850nm的波长。照射疗程是在腹下区域经腹进行的。考虑的结果是生化妊娠，血液妊娠试验呈阳性，和临床妊娠，通过超声检查孕囊的可视化确认。结果:受试者平均年龄34.17岁,他们之前经历了三到七次胚胎移植。激光治疗组与对照组之间的基本特征没有显着差异。然而,与对照组相比，激光治疗组的生化和临床妊娠率均升高（46.7％vs.33.3%；P==0.710和33.3%vs.20.0%；分别P=0.682）。结论：据我们所知，本研究是第一项单盲随机临床试验,旨在评估LLLT预处理对RIF患者的有效性.研究结果表明，LLLT可能会提高RIF患者的生化和临床妊娠率。
