UNASSIGNED: We used the bidirectional Two-sample Mendelian randomization (TSMR) method to evaluate the causal relationship between BPD and AF. Instrumental variables associated with BPD were derived from a genome-wide association study involving 214,816 Europeans (2,637 cases and 212,179 controls). We then obtained atrial fibrillation data from the GWAS meta-analysis (60,620 cases and 970,216 controls). The TSMR analyses were performed in five methods, namely fixed-effect inverse-variance weighted (IVW) method、random-effect IVW method, MR Egger regression method, Weighted median method and Simple mode method. Several sensitivity analyses are used to test the robustness of positive results.
UNASSIGNED: The fixed-effect inverse-variance weighted model [Odds ratio (OR), 1.033, 95% confidence interval (CI), 1.011-1.056, P = 0.0031], random-effect inverse-variance weighted model (OR, 1.033; 95%CI, 1.005-1.062; P = 0.0191) and Weighted median (OR, 1.034; 95%CI, 1.002-1.068; P = 0.0394) all showed that genetically predicted BPD was associated with an increased risk of AF. Sensitivity analysis using other MR Methods, including the MR-Egger intercept, MR-Presso method, and leave-one-out analyses, showed that the results were robust. In reverse MR analysis, there was no causal relationship of AF on BPD.
UNASSIGNED: Our study provides a causal relationship between BPD and AF. This means that patients with BPD should be monitored for the occurrence of AF. Early screening and proper management of BPD may show anti-arrhythmic benefits.
■我们使用双向双样本孟德尔随机化(TSMR)方法评估了BPD与AF之间的因果关系。与BPD相关的仪器变量来自涉及214,816名欧洲人(2,637例和212,179名对照)的全基因组关联研究。然后,我们从GWAS荟萃分析中获得了心房颤动数据(60,620例和970,216例对照)。TSMR分析采用五种方法进行,即固定效应方差逆加权(IVW)法、随机效应IVW法、MREgger回归方法,加权中位数法和简单模态法。几种敏感性分析用于测试阳性结果的稳健性。
■固定效应逆方差加权模型[赔率(OR),1.033,95%置信区间(CI),1.011-1.056,P=0.0031],随机效应逆方差加权模型(OR,1.033;95CI,1.005-1.062;P=0.0191)和加权中位数(OR,1.034;95CI,1.002-1.068;P=0.0394)均显示遗传预测的BPD与AF风险增加相关。使用其他MR方法进行敏感性分析,包括MR-Egger截距,MR-Presso方法,和遗漏分析,表明结果是稳健的。在反向MR分析中,房颤与BPD无因果关系。
■我们的研究提供了BPD和AF之间的因果关系。这意味着应监测患有BPD的患者是否发生AF。早期筛查和BPD的适当管理可能显示出抗心律失常的益处。