PDF(Pubmed)
Abstract：
Skeletal muscle is one of the tissues with the highest ability to regenerate, a finely controlled process which is critically depending on muscle stem cells. Muscle stem cell functionality depends on intrinsic signaling pathways and interaction with their immediate niche. Upon injury quiescent muscle stem cells get activated, proliferate and fuse to form new myofibers, a process involving the interaction of multiple cell types in regenerating skeletal muscle. Receptors in muscle stem cells receive the respective signals through direct cell-cell interaction, signaling via secreted factors or cell-matrix interactions thereby regulating responses of muscle stem cells to external stimuli. Here, we discuss how muscle stem cells interact with their immediate niche focusing on how this controls their quiescence, activation and self-renewal and how these processes are altered in age and disease.
摘要：
骨骼肌是再生能力最高的组织之一，一个精细控制的过程，关键取决于肌肉干细胞。肌肉干细胞功能取决于内在信号通路和与其直接生态位的相互作用。受伤后，静止的肌肉干细胞被激活，增殖并融合形成新的肌纤维，涉及骨骼肌再生中多种细胞类型相互作用的过程。肌肉干细胞中的受体通过直接的细胞-细胞相互作用接收各自的信号，通过分泌因子或细胞-基质相互作用的信号传导，从而调节肌肉干细胞对外部刺激的反应。这里,我们讨论了肌肉干细胞如何与它们的直接生态位相互作用，重点是如何控制它们的静止，激活和自我更新，以及这些过程如何在年龄和疾病中改变。
