PDF(Pubmed)
Abstract：
Retinal organoids are three-dimensional (3D) microscopic tissues that are induced and differentiated from stem cells or progenitor cells in vitro and have a highly similar structure to the retina. With the optimization and development of 3D retinal culture system and the improvement of induced differentiation technology, retinal organoids have broad application prospects in retinal development, regenerative medicine, biomaterial evaluation, disease mechanism investigation, and drug screening. In this review we summarize recent development of retinal organoids and their applications in ophthalmic regenerative medicine. In particular, we highlight the promise and challenges in the use of retinal organoids in disease modeling and drug discovery.
摘要：
视网膜类器官是在体外从干细胞或祖细胞诱导和分化的三维(3D)显微组织,并且具有与视网膜高度相似的结构。随着3D视网膜培养系统的优化和发展以及诱导分化技术的提高,视网膜类器官在视网膜发育中具有广阔的应用前景,再生医学,生物材料评价，疾病机制调查，和药物筛选。在这篇综述中，我们总结了视网膜类器官的最新发展及其在眼科再生医学中的应用。特别是,我们强调了在疾病建模和药物发现中使用视网膜类器官的前景和挑战。
