PDF(Pubmed)
Abstract：
Male infertility is significantly affected by bacteriospermia, defined by the presence of bacteria in semen. This case report aims to address the effects of bacteriospermia and its correlation with semen characteristics, sperm DNA fragmentation (SDF), and reproductive outcomes. The 33-year-old male was diagnosed with bacteriospermia caused by two gram-negative bacteria: Escherichia coli and Klebsiella pneumoniae. It was found that sperm parameters such as mobility, number, and morphology were compromised in sperm, indicating poor fertility. In addition, SDF analysis has revealed a high DNA fragmentation index (DFI), emphasizing the detrimental effects of bacteriospermia on the integrity of sperm. Antibiotic therapy and antioxidant supplements have been used as therapeutic measures to reduce the impact of bacterial infections and DNA damage caused by oxidative stress (OS). Follow-up assessments showed significant improvements in the integrity of the sperm DNA and the resolution of microbial colonization, which ultimately led to successful in vitro fertilization (IVF) and embryo transfer (ET), leading to a positive pregnancy outcome.
摘要：
男性不育受到细菌精子症的显著影响，由精液中细菌的存在定义。该病例报告旨在解决细菌精子症的影响及其与精液特征的相关性。精子DNA片段（SDF），和生殖结果。这名33岁的男性被诊断为由两种革兰氏阴性菌引起的细菌精子症：大肠杆菌和肺炎克雷伯菌。结果发现，精子参数，如流动性，number,精子形态受损，说明生育率差。此外,SDF分析揭示了高DNA片段化指数(DFI)，强调细菌精子症对精子完整性的有害影响。抗生素治疗和抗氧化剂补充剂已被用作治疗措施，以减少由氧化应激（OS）引起的细菌感染和DNA损伤的影响。后续评估显示精子DNA的完整性和微生物定植的分辨率显著改善，最终导致成功的体外受精（IVF）和胚胎移植（ET），导致积极的妊娠结果。
