PDF(Pubmed)
Abstract：
Traumatic brain injury (TBI) stands as a significant contributor to traumatic death and disability worldwide. In recent years, researchers have identified biomarkers to gauge useful outcomes in TBI patients. However, the enigma of timely sample collection to measure the biomarkers remains a controversial point in the case of TBI, unlike other degenerative diseases like Alzheimer\'s disease and Parkinson\'s disease, where we can collect the sample at any point in time. The purpose of this study is to evaluate the sensitivity of biomarkers in TBI concerning time of injury by analyzing recent available data on biomarkers in the medical literature. A total of 2,256 studies were initially retrieved from the search engine. After an initial screening, only 1,750 unique articles remained. After excluding review articles, animal studies, meta-analysis, and studies with children (screened by title and abstract), 30 kinds of literature were found relevant to search the required variables. Further 16 studies were excluded due to the nonavailability of complete variables or data. Finally, 14 studies remained and were included in the analysis. This study has analyzed the four most commonly described biomarkers for TBI in the literature: glial fibrillary acidic protein (GFAP), S100 calcium-binding protein B, ubiquitin carboxy-terminal hydrolase L1, and Tau. According to this statistical analysis, all biomarkers included in the study have shown their serum levels after trauma. So, all these biomarkers can be used for further study in the outcome prediction and diagnosis of TBI patients. The meta-analysis suggests that the best biomarker for TBI is Tau in cases where sample collection is done within 24 hours, while GFAP is the best biomarker to be studied for TBI if sample collection is done 24 hours after trauma.
摘要：
创伤性脑损伤（TBI）是全球范围内创伤性死亡和残疾的重要原因。近年来,研究人员已经确定了生物标志物来衡量TBI患者的有用结局.然而,在TBI的情况下，及时收集样本以测量生物标志物的谜团仍然是一个有争议的问题，与其他退行性疾病如阿尔茨海默病和帕金森病不同，我们可以在任何时间点收集样本。这项研究的目的是通过分析医学文献中有关生物标志物的最新可用数据来评估TBI中有关损伤时间的生物标志物的敏感性。最初从搜索引擎检索了总共2,256项研究。经过初步筛选,只剩下1750篇独特文章。排除评论文章后，动物研究,荟萃分析，和儿童研究（按标题和摘要筛选），找到了30种与搜索所需变量相关的文献。由于无法获得完整的变量或数据，因此排除了另外16项研究。最后,14项研究仍然存在，并包括在分析中。本研究分析了文献中最常见的四种TBI生物标志物：胶质纤维酸性蛋白（GFAP），S100钙结合蛋白B,泛素羧基末端水解酶L1和Tau。根据统计分析,研究中包括的所有生物标志物均显示了创伤后的血清水平.所以,所有这些生物标志物均可用于TBI患者预后预测和诊断的进一步研究.荟萃分析表明，在24小时内完成样本收集的情况下，TBI的最佳生物标志物是Tau，而如果在创伤后24小时进行样品收集，GFAP是TBI研究的最佳生物标志物。
