PDF(Pubmed)
Abstract：
Anaplastic large T/null cell lymphoma (ALCL) is an aggressive non-Hodgkin\'s lymphoma (NHL) that most commonly affects young men. Herein, we present a case of a 32-year-old male patient in severe condition with ulcerated right axillary adenopathy, diffuse subcutaneous nodules, and sepsis. He was admitted to the ED, where a bone marrow aspirate and biopsy confirmed the diagnosis of ALCL. The immunohistochemical examination demonstrated neoplastic cells with immunopositivity with antibodies CD3 (focal), CD30 (diffuse), protein ALK-1 (diffuse), and epithelial membrane antigen (EMA) (multifocal). Appropriate chemotherapy treatment was done, and the patient showed a complete response. This article aims to report a rare subtype of NHL to increase awareness and bring up a discussion about the clinical presentation and diagnostic features of ALCL. Moreover, we discuss treatment regimens that are currently used and have shown reasonable disease remission rates.
摘要：
间变性大T/无效细胞淋巴瘤（ALCL）是一种侵袭性非霍奇金淋巴瘤（NHL），最常影响年轻男性。在这里，我们介绍了一例32岁的男性患者，患有严重的溃疡右腋窝腺病，弥漫性皮下结节,还有败血症.他被允许进入急诊室,骨髓穿刺和活检证实了ALCL的诊断。免疫组织化学检查显示肿瘤细胞与抗体CD3（病灶）免疫阳性，CD30（弥漫性），蛋白质ALK-1（弥漫性），和上皮膜抗原（EMA）（多灶性）。进行了适当的化疗治疗，患者表现出完全的反应。本文旨在报道一种罕见的NHL亚型，以提高人们的认识，并对ALCL的临床表现和诊断特征进行讨论。此外，我们讨论了目前使用的治疗方案，并显示出合理的疾病缓解率。
