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Abstract：
BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is a rapidly growing malignant tumor, and chemotherapy is one of the treatments used to combat it. Although advancements of science and technology have resulted in more and more patients being able to receive effective treatment, they still face side effects such as fatigue and weakness. It is important to thoroughly investigate the factors that contribute to cancer-related fatigue (CRF) during chemotherapy.
OBJECTIVE: To explore the factors related to CRF, anxiety, depression, and mindfulness levels in patients with DLBCL during chemotherapy.
METHODS: General information was collected from the electronic medical records of eligible patients. Sleep quality and mindfulness level scores in patients with DLBCL during chemotherapy were evaluated by the Pittsburgh Sleep Quality Index and Five Facet Mindfulness Questionnaire-Short Form. The Piper Fatigue Scale was used to evaluate the CRF status. The Self-Rating Anxiety Scale and Self-Rating Depression Scale were used to evaluate anxiety and depression status. Univariate analysis and multivariate regression analysis were used to investigate the factors related to CRF.
RESULTS: The overall average CRF level in 62 patients with DLBCL during chemotherapy was 5.74 ± 2.51. In 25 patients, the highest rate of mild fatigue was in the cognitive dimension (40.32%), and in 35 patients the highest moderate fatigue rate in the behavioral dimension (56.45%). In the emotional dimension, severe fatigue had the highest rate of occurrence, 34 cases or 29.03%. The CRF score was positively correlated with cancer experience (all P < 0.01) and negatively correlated with cancer treatment efficacy (all P < 0.01). Tumor staging, chemotherapy cycle, self-efficacy level, and anxiety and depression level were related to CRF in patients with DLBCL during chemotherapy.
CONCLUSIONS: There was a significant correlation between CRF and perceptual control level in patients. Tumor staging, chemotherapy cycle, self-efficacy level, and anxiety and depression level influenced CRF in patients with DLBCL during chemotherapy.
OBJECTIVE: To explore the factors related to CRF, anxiety, depression, and mindfulness levels in patients with DLBCL during chemotherapy.
METHODS: General information was collected from the electronic medical records of eligible patients. Sleep quality and mindfulness level scores in patients with DLBCL during chemotherapy were evaluated by the Pittsburgh Sleep Quality Index and Five Facet Mindfulness Questionnaire-Short Form. The Piper Fatigue Scale was used to evaluate the CRF status. The Self-Rating Anxiety Scale and Self-Rating Depression Scale were used to evaluate anxiety and depression status. Univariate analysis and multivariate regression analysis were used to investigate the factors related to CRF.
RESULTS: The overall average CRF level in 62 patients with DLBCL during chemotherapy was 5.74 ± 2.51. In 25 patients, the highest rate of mild fatigue was in the cognitive dimension (40.32%), and in 35 patients the highest moderate fatigue rate in the behavioral dimension (56.45%). In the emotional dimension, severe fatigue had the highest rate of occurrence, 34 cases or 29.03%. The CRF score was positively correlated with cancer experience (all P < 0.01) and negatively correlated with cancer treatment efficacy (all P < 0.01). Tumor staging, chemotherapy cycle, self-efficacy level, and anxiety and depression level were related to CRF in patients with DLBCL during chemotherapy.
CONCLUSIONS: There was a significant correlation between CRF and perceptual control level in patients. Tumor staging, chemotherapy cycle, self-efficacy level, and anxiety and depression level influenced CRF in patients with DLBCL during chemotherapy.
摘要：
背景：弥漫性大B细胞淋巴瘤（DLBCL）是一种快速增长的恶性肿瘤，化疗是用来对抗它的治疗方法之一。虽然科学技术的进步使得越来越多的患者能够得到有效的治疗,他们仍然面临着疲劳和虚弱等副作用。彻底研究化疗期间导致癌症相关性疲劳（CRF）的因素非常重要。
目的：探讨CRF的相关因素，焦虑,抑郁症,化疗期间DLBCL患者的正念水平。
方法：从符合条件的患者的电子病历中收集一般信息。通过匹兹堡睡眠质量指数和五方面正念问卷简表评估DLBCL患者化疗期间的睡眠质量和正念水平评分。Piper疲劳量表用于评估CRF状态。采用焦虑自评量表和抑郁自评量表评价焦虑和抑郁状态。采用单因素分析和多因素回归分析探讨CRF的相关因素。
结果：62例DLBCL患者化疗期间的CRF总体平均水平为5.74±2.51。在25名患者中，轻度疲劳率最高的是认知维度(40.32%)，35例患者行为维度中度疲劳率最高(56.45%)。在情感层面，严重疲劳发生率最高，34例,占29.03%。CRF评分与癌症治疗经验呈正相关（均P<0.01），与癌症治疗疗效呈负相关（均P<0.01）。肿瘤分期,化疗周期,自我效能水平,DLBCL患者化疗期间焦虑、抑郁水平与CRF相关。
结论：患者CRF与知觉控制水平之间存在显著相关性。肿瘤分期,化疗周期,自我效能水平,焦虑和抑郁水平影响DLBCL患者化疗期间的CRF。
目的：探讨CRF的相关因素，焦虑,抑郁症,化疗期间DLBCL患者的正念水平。
方法：从符合条件的患者的电子病历中收集一般信息。通过匹兹堡睡眠质量指数和五方面正念问卷简表评估DLBCL患者化疗期间的睡眠质量和正念水平评分。Piper疲劳量表用于评估CRF状态。采用焦虑自评量表和抑郁自评量表评价焦虑和抑郁状态。采用单因素分析和多因素回归分析探讨CRF的相关因素。
结果：62例DLBCL患者化疗期间的CRF总体平均水平为5.74±2.51。在25名患者中，轻度疲劳率最高的是认知维度(40.32%)，35例患者行为维度中度疲劳率最高(56.45%)。在情感层面，严重疲劳发生率最高，34例,占29.03%。CRF评分与癌症治疗经验呈正相关（均P<0.01），与癌症治疗疗效呈负相关（均P<0.01）。肿瘤分期,化疗周期,自我效能水平,DLBCL患者化疗期间焦虑、抑郁水平与CRF相关。
结论：患者CRF与知觉控制水平之间存在显著相关性。肿瘤分期,化疗周期,自我效能水平,焦虑和抑郁水平影响DLBCL患者化疗期间的CRF。
