PDF(Pubmed)
Abstract：
UNASSIGNED: Comprehensive long-term follow-up data regarding chronic spontaneous urticaria (CSU) among general populations, especially from the Indian subcontinent is scanty.
UNASSIGNED: The aim of the study were to analyze the clinico-epidemiological profile, comorbidities of CSU patients, and factors affecting patient response to various doses of levocetirizine.
UNASSIGNED: In this retrospective cohort study, complete history regarding demographic profile, clinical examination, investigations, treatment given, and follow-up details of all CSU patients attending urticaria clinic between 2010 and 2019 were analyzed. These were considered variables to determine the factors playing a role in response to various doses of levocetirizine.
UNASSIGNED: Totally, 1104 files of CSU were analyzed. The male-to-female ratio was 1:1.5 with a mean age of 33.03 ± 14.33 years. Thyroid dysfunction and atopy were seen in 142 (12.8%) and 184 (16.7%) patients, respectively. Vitamin D deficiency and high serum immunoglobulin E (IgE) levels were seen in 461 (41.7%) and 340 (30.7%) patients, respectively. Immunosuppressives were required at some point in 196 (17.7%) patients. Patients with higher levels of serum IgE and D-dimer (P < 0.05) were found to require frequent updosing of levocetirizine, while age, sex, duration of illness, presence of angioedema, co-morbidities, identifiable precipitating factors, presence of diurnal variation, family history, and vitamin D deficiency were found to not have an effect on levocetirizine dosing.
UNASSIGNED: Ours is a large single-center study exemplifying the biomarkers including baseline serum IgE and D-dimer levels, which could identify a CSU patient who could warrant a higher dose of antihistamine/antihistamine refractory urticaria.
UNASSIGNED: The aim of the study were to analyze the clinico-epidemiological profile, comorbidities of CSU patients, and factors affecting patient response to various doses of levocetirizine.
UNASSIGNED: In this retrospective cohort study, complete history regarding demographic profile, clinical examination, investigations, treatment given, and follow-up details of all CSU patients attending urticaria clinic between 2010 and 2019 were analyzed. These were considered variables to determine the factors playing a role in response to various doses of levocetirizine.
UNASSIGNED: Totally, 1104 files of CSU were analyzed. The male-to-female ratio was 1:1.5 with a mean age of 33.03 ± 14.33 years. Thyroid dysfunction and atopy were seen in 142 (12.8%) and 184 (16.7%) patients, respectively. Vitamin D deficiency and high serum immunoglobulin E (IgE) levels were seen in 461 (41.7%) and 340 (30.7%) patients, respectively. Immunosuppressives were required at some point in 196 (17.7%) patients. Patients with higher levels of serum IgE and D-dimer (P < 0.05) were found to require frequent updosing of levocetirizine, while age, sex, duration of illness, presence of angioedema, co-morbidities, identifiable precipitating factors, presence of diurnal variation, family history, and vitamin D deficiency were found to not have an effect on levocetirizine dosing.
UNASSIGNED: Ours is a large single-center study exemplifying the biomarkers including baseline serum IgE and D-dimer levels, which could identify a CSU patient who could warrant a higher dose of antihistamine/antihistamine refractory urticaria.
摘要：
■关于一般人群中慢性自发性荨麻疹（CSU）的综合长期随访数据，特别是来自印度次大陆的人很少。
■这项研究的目的是分析临床流行病学概况，CSU患者的合并症，以及影响患者对各种剂量左西替利嗪反应的因素。
■在这项回顾性队列研究中，关于人口统计概况的完整历史，临床检查,调查,给予治疗，并分析2010年至2019年所有在荨麻疹门诊就诊的CSU患者的随访细节。这些被认为是变量，以确定在响应各种剂量的左西替利嗪中起作用的因素。
■完全,分析了1104个CSU文件。男女比例为1：1.5，平均年龄为33.03±14.33岁。142例(12.8%)和184例(16.7%)患者出现甲状腺功能异常和特应性,分别。461例(41.7%)和340例(30.7%)患者出现维生素D缺乏和血清免疫球蛋白E(IgE)水平升高,分别。196例（17.7%）患者在某些时候需要免疫抑制剂。血清IgE和D-二聚体水平较高（P<0.05）的患者需要频繁增加左西替利嗪，而年龄,性别,疾病的持续时间,血管性水肿的存在，合并症,可识别的沉淀因素，存在昼夜变化，家族史,发现维生素D缺乏对左西替利嗪剂量没有影响。
■我们是一项大型单中心研究，举例说明了包括基线血清IgE和D-二聚体水平在内的生物标志物。这可以确定CSU患者谁可以要求更高剂量的抗组胺/抗组胺难治性荨麻疹。
■这项研究的目的是分析临床流行病学概况，CSU患者的合并症，以及影响患者对各种剂量左西替利嗪反应的因素。
■在这项回顾性队列研究中，关于人口统计概况的完整历史，临床检查,调查,给予治疗，并分析2010年至2019年所有在荨麻疹门诊就诊的CSU患者的随访细节。这些被认为是变量，以确定在响应各种剂量的左西替利嗪中起作用的因素。
■完全,分析了1104个CSU文件。男女比例为1：1.5，平均年龄为33.03±14.33岁。142例(12.8%)和184例(16.7%)患者出现甲状腺功能异常和特应性,分别。461例(41.7%)和340例(30.7%)患者出现维生素D缺乏和血清免疫球蛋白E(IgE)水平升高,分别。196例（17.7%）患者在某些时候需要免疫抑制剂。血清IgE和D-二聚体水平较高（P<0.05）的患者需要频繁增加左西替利嗪，而年龄,性别,疾病的持续时间,血管性水肿的存在，合并症,可识别的沉淀因素，存在昼夜变化，家族史,发现维生素D缺乏对左西替利嗪剂量没有影响。
■我们是一项大型单中心研究，举例说明了包括基线血清IgE和D-二聚体水平在内的生物标志物。这可以确定CSU患者谁可以要求更高剂量的抗组胺/抗组胺难治性荨麻疹。
