PDF(Pubmed)
Abstract：
Adhesion molecule with IgG-like domain 2 (AMIGO2) is a novel scaffold protein initially identified in cerebellar granule neurons, and inhibits apoptosis of neurons. It is also widely expressed in various malignant tumors, including gastric cancer, colorectal carcinoma, ovarian cancer, prostate cancer and melanoma. During the past decades, it has been revealed that AMIGO2 can act as an oncogene, participating in tumor occurrence and development, for example by inhibiting apoptosis, accelerating cell proliferation, migration and adhesion, and promoting tumor metastasis and drug resistance. The present review discusses the recent advancements regarding AMIGO2 in the field of cancer, emphasizing its related molecular mechanisms to identify novel therapeutic strategies targeting AMIGO2 for cancer treatment in the future.
摘要：
具有IgG样结构域2的粘附分子(AMIGO2)是最初在小脑颗粒神经元中发现的新型支架蛋白,并抑制神经元的凋亡。它在各种恶性肿瘤中也广泛表达，包括胃癌,大肠癌,卵巢癌,前列腺癌和黑色素瘤.在过去的几十年里，据透露，AMIGO2可以充当癌基因，参与肿瘤的发生和发展,例如通过抑制细胞凋亡，加速细胞增殖，迁移和粘附，促进肿瘤转移和耐药。本综述讨论了关于AMIGO2在癌症领域的最新进展，强调其相关的分子机制，以确定未来针对AMIGO2的癌症治疗新的治疗策略。
