PDF(Pubmed)
Abstract：
Gait impairment and neurogenic bladder are co-existing common findings in incomplete spinal cord injury (iSCI). Repetitive transcranial magnetic stimulation (rTMS), evident to be a promising strategy adjunct to physical rehabilitation to regain normal ambulation in SCI. However, there is a need to evaluate the role of Intermittent theta burst stimulation (iTBS), a type of patterned rTMS in restoring gait and neurogenic bladder in SCI patients. The aim of the present study is to quantify the effect of iTBS on spatiotemporal, kinetic, and kinematic parameters of gait and neurogenic bladder dyssynergia in iSCI. After maturing all exclusion and inclusion criteria, thirty iSCI patients will be randomly divided into three groups: Group-A (sham), Group-B (active rTMS) and Group-C (active iTBS). Each group will receive stimulation adjunct to physical rehabilitation for 2 weeks. All patients will undergo gait analysis, as well assessment of bladder, electrophysiological, neurological, functional, and psychosocial parameters. All parameters will be assessed at baseline and 6th week (1st follow-up). Parameters except urodynamics and gait analysis will also be assessed after the end of the 2 weeks of the intervention (post-intervention) and at 12th week (2nd follow-up). Appropriate statistical analysis will be done using various parametric and non-parametric tests based on results.
摘要：
步态障碍和神经源性膀胱是不完全脊髓损伤（iSCI）的共同发现。重复经颅磁刺激(rTMS),显然是一种有希望的策略，可以辅助身体康复以恢复正常运动。然而,有必要评估间歇性θ爆发刺激(iTBS)的作用，一种在SCI患者中恢复步态和神经源性膀胱的图案化rTMS。本研究的目的是量化iTBS对时空的影响，动力学,iSCI中步态和神经源性膀胱协同失调的运动学参数。在所有排除和纳入标准成熟后，将30名iSCI患者随机分为三组：A组（假），B组(活性rTMS)和C组(活性iTBS)。每组将接受2周的物理康复辅助刺激。所有患者都将接受步态分析，以及膀胱的评估，电生理学,神经学,功能，和心理社会参数。将在基线和第6周(第1次随访)评估所有参数。除了尿动力学和步态分析之外的参数也将在干预2周结束后(干预后)和第12周(第二次随访)进行评估。将根据结果使用各种参数和非参数检验进行适当的统计分析。
