PDF(Pubmed)
Abstract：
This study aimed to assess the significance of serum albumin levels within 24 h of patient admission in correlation with the incidence of outcomes and mortality in patients diagnosed with acute pancreatitis. A retrospective study was conducted over a 5-year period, from January 2018 to December 2023, at the Mohammed VI University Hospital in Oujda, Morocco. The study included 371 patients diagnosed with acute pancreatitis. Hypoalbuminemia (≤ 30 g/L) was observed in 124 patients (33.4% of cases), and these patients had a higher mean age compared to those with normal albumin levels (P = 0.003). Hypoalbuminemia was significantly associated with persistent Systemic Inflammatory Response Syndrome (SIRS) (70.8% vs. 29.2%, P = 0.000), a higher BISAP score (66.7% vs. 33.3%, P = 0.000), and a higher CTSI score (51.7% vs. 48.3%, P = 0.000). Hypoalbuminemia was also associated with the presence of pleural effusion (P = 0.000). The mortality in the sample was 4.6%, and it was significantly associated with hypoalbuminemia (76.5%, P = 0.000). In conclusion, serum albumin levels within 24 h of patient admission appear to be a significant prognostic biomarker in acute pancreatitis, particularly in anticipating persistent organ failure and mortality.
摘要：
本研究旨在评估患者入院后24小时内血清白蛋白水平与诊断为急性胰腺炎的患者预后和死亡率的相关性。进行了为期5年的回顾性研究，从2018年1月到2023年12月，在乌吉达的穆罕默德六世大学医院，摩洛哥。该研究包括371例诊断为急性胰腺炎的患者。低白蛋白血症（≤30g/L）在124例（33.4％的病例）中观察到，与白蛋白水平正常的患者相比,这些患者的平均年龄更高(P=0.003).低白蛋白血症与持续性全身炎症反应综合征（SIRS）（70.8%vs.29.2%,P=0.000),更高的BISAP得分(66.7%vs.33.3%,P=0.000),和更高的CTSI评分(51.7%vs.48.3%,P=0.000)。低白蛋白血症也与胸腔积液有关(P=0.000)。样本中的死亡率为4.6%，并且与低蛋白血症显着相关（76.5％，P=0.000)。总之,患者入院24小时内的血清白蛋白水平似乎是急性胰腺炎的重要预后生物标志物，特别是在预期持续的器官衰竭和死亡率。
