Abstract：
The study aimed to investigate the repercussions of androgen modulation on the adrenal cortex of male gerbils, focusing on the morphophysiology, proliferation, and cell death, as well as the expression of hormone receptors and steroidogenic enzymes. Mongolian gerbils (Meriones unguiculatus) were divided into three experimental groups: Control (C), Testosterone (T), animals received injections of testosterone cypionate and Castrated (Ct), animals underwent orchiectomy. The results showed that castration increased the zona fasciculata and promoted cell hypertrophy in all zones. Testosterone supplementation increased cell proliferation and cell death. Androgen modulation promoted an increase in AR, Erα, and ERβ. Castration promoted an increase in the CYP19, while decreasing 17βHSD enzymes. Testosterone supplementation, on the other hand, reduced CYP17 and increased CYP19 and 3βHSD enzymes. By analyzing the effects of androgen supplementation and deprivation, it can be concluded that testosterone is responsible for tissue remodeling in the cortex, regulating the rate of cell proliferation and death, as well as cell hypertrophy. Testosterone also modulate steroid hormone receptors and steroidogenic enzymes, consequently affecting the regulation, hormone synthesis and homeostasis of this endocrine gland.
摘要：
本研究旨在探讨雄激素调节对雄性沙鼠肾上腺皮质的影响,专注于形态生理学，扩散,和细胞死亡，以及激素受体和类固醇生成酶的表达。蒙古沙鼠（Merionesunguiculatus）分为三个实验组：对照组（C），睾酮(T),动物接受注射睾酮环戊酸盐和去势(Ct)，动物接受睾丸切除术。结果表明，去势增加了束状带，促进了所有区域的细胞肥大。睾酮补充增加细胞增殖和细胞死亡。雄激素调节促进AR的增加，呃α,和ERβ。去势促进CYP19的增加，同时减少17βHSD酶。补充睾酮,另一方面,降低CYP17，增加CYP19和3βHSD酶。通过分析雄激素补充和剥夺的效果，可以得出结论，睾丸激素负责皮质中的组织重塑，调节细胞增殖和死亡的速度，以及细胞肥大。睾酮还调节类固醇激素受体和类固醇生成酶，因此影响了法规，这种内分泌腺的激素合成和稳态。
