Abstract：
Candida spp. are commonly a group of opportunistic dimorphic fungi, frequently causing diverse fungal infections in immunocompromised or immunosuppressant patients from mucosal disturbs (oropharyngeal candidiasis and vulvovaginal candidiasis) to disseminated infections (systemic candidiasis) with high morbidity and mortality. Importantly, several Candida species can be isolated from diseased individuals with digestive, neuropathic, respiratory, metabolic and autoimmune diseases. Due to increased resistance to conventional antifungal agents, the arsenal for antifungal purpose is in urgent need. Traditional Chinese Medicines (TCMs) are a huge treasury that can be used as promising candidates for antimycotic applications. In this review, we make a short survey of microbiological (morphology and virulence) and pathological (candidiasis and Candida related infections) features of and host immune response (innate and adaptive immunity) to Candida spp.. Based on the chemical structures and well-studied antifungal mechanisms, the monomers, extracts, decoctions, essential oils and other preparations of TCMs that are reported to have fair antifungal activities or immunomodulatory effects for anticandidal purpose are comprehensively reviewed. We also emphasize the importance of combination and drug pair of TCMs as useful anticandidal strategies, as well as network pharmacology and molecular docking as beneficial complements to current experimental approaches. This review construct a therapeutic module that can be helpful to guide in-future experimental and preclinical studies in the combat against fungal threats aroused by C. albicans and non-albicans Candida species.
摘要：
念珠菌属。通常是一组机会性二态真菌，经常在免疫功能低下或免疫抑制剂患者中引起多种真菌感染，从粘膜紊乱（口咽念珠菌病和外阴阴道念珠菌病）到播散性感染（系统性念珠菌病），发病率和死亡率高。重要的是,可以从患有消化系统的患病个体中分离出几种念珠菌，神经病,呼吸,代谢和自身免疫性疾病。由于对常规抗真菌药物的耐药性增加，急需用于抗真菌的武器库。传统中药（TCM）是一个巨大的宝库，可以用作抗真菌剂应用的有希望的候选人。在这次审查中,我们对念珠菌的微生物学（形态和毒力）和病理学（念珠菌病和念珠菌相关感染）特征以及宿主对念珠菌的免疫反应（先天和适应性免疫）进行了简短调查。.基于化学结构和充分研究的抗真菌机制，单体，摘录,汤剂,全面审查了精油和其他据报道具有良好抗真菌活性或免疫调节作用的TCM制剂。我们还强调了TCM的组合和药物对作为有用的抗虫策略的重要性，以及网络药理学和分子对接作为当前实验方法的有益补充。这篇综述构建了一个治疗模块，可有助于指导未来的实验和临床前研究，以对抗白色念珠菌和非白色念珠菌引起的真菌威胁。
