Abstract：
A naturally occurring stilbene, resveratrol, shows promising effects in the treatment of malignant pleural mesothelioma (MPM) both as a single agent and in combination with chemotherapeutic drugs. To discover new anticancer agents targeting MPM, stilbene-targeted isolation was performed on the roots of Polygonum multiflorum Thunb., an herbal medicine rich in stilbene compounds. In this study, seven stilbene glycosides (1-7) were isolated, along with four non-stilbenes (8-11), of which compounds 4 and 9-11 have not previously been isolated from this species. Stiquinoside A (1) is a previously undescribed stilbene glycoside, and its structure was elucidated as (E)-2,3,5,4\'-tetrahydroxystilbene 2-O-β-d-quinovopyranoside based on 1D and 2D-NMR, HR-ESI-MS, and acid hydrolysis experiments. Compounds 1, 4, 6, and 8 significantly inhibit the growth of MPM cancer cells H2452. These results demonstrate the potential utility of stilbenes in new strategies for the treatment of MPM.
摘要：
一种天然存在的二苯乙烯，白藜芦醇,作为单一药物和与化疗药物联合治疗恶性胸膜间皮瘤（MPM）均显示出有希望的效果。为了发现靶向MPM的新抗癌药物，对何首乌的根进行了二苯乙烯靶向分离。,富含二苯乙烯化合物的草药。在这项研究中,分离出七个二苯乙烯苷（1-7），连同四个非苯乙烯（8-11），其中化合物4和9-11以前从未从该物种中分离出来。StiquinosideA（1）是以前未描述的二苯乙烯糖苷，基于1D和2D-NMR，其结构被阐明为（E）-2,3,5,4'-四羟基二苯乙烯2-O-β-d-喹吡喃糖苷，HR-ESI-MS,和酸水解实验。化合物1、4、6和8显著抑制MPM癌细胞H2452的生长。这些结果证明了二苯乙烯在治疗MPM的新策略中的潜在效用。
