在单细胞分辨率下分析胚胎休眠揭示了动态转录反应和整合素 - Yap / Taz 促生存信号的激活。
关键词: Taz Yap embryo dormancy embryonic diapause embryonic stem cells epiblast extracellular matrix integrin pluripotency single-cell RNA sequencing
Mesh : Animals YAP-Signaling Proteins / metabolism Signal Transduction Mice Single-Cell Analysis Integrins / metabolism Embryo, Mammalian / metabolism Adaptor Proteins, Signal Transducing / metabolism genetics Transcription, Genetic Gene Expression Regulation, Developmental Embryonic Development / genetics Cell Survival Transcription Factors / metabolism genetics Transcriptional Coactivator with PDZ-Binding Motif Proteins Diapause
来 源: DOI:10.1016/j.stem.2024.06.015