Abstract：
Embryonic diapause is a reproductive adaptation that enables some mammalian species to halt the otherwise continuous pace of embryonic development. In this dormant state, the embryo exploits poorly understood regulatory mechanisms to preserve its developmental potential for prolonged periods of time. Here, using mouse embryos and single-cell RNA sequencing, we molecularly defined embryonic diapause at single-cell resolution, revealing transcriptional dynamics while the embryo seemingly resides in a state of suspended animation. Additionally, we found that the dormant pluripotent cells rely on integrin receptors to sense their microenvironment and preserve their viability via Yap/Taz-mediated prosurvival signaling.
摘要：
胚胎滞育是一种生殖适应，使一些哺乳动物物种能够停止胚胎发育的其他连续步伐。在这个休眠状态下,胚胎利用知之甚少的调节机制来长时间保持其发育潜力。这里,使用小鼠胚胎和单细胞RNA测序，我们在单细胞分辨率下分子定义了胚胎滞育，揭示转录动力学，而胚胎似乎处于悬浮动画状态。此外,我们发现,休眠的多能细胞依赖于整合素受体来感知其微环境,并通过Yap/Taz介导的促存活信号维持其生存能力.
