Abstract：
Due to its numerous biological activities, such as antioxidant, anti-inflammatory, antitumor, anti-atherosclerosis, anti-aging, anti-osteoporosis, anti-obesity, estrogenic, neuroprotective and cardioprotective effects, resveratrol has attracted a lot of attention in the food and pharmaceutical industries as a promising bioactive. However, low solubility in aqueous media, limited bioavailability, and low stability of resveratrol in hostile environments limit its applications. The necessity for a summary of recent developments is highlighted by the growing body of research on resveratrol encapsulation as a means of overcoming the mentioned application constraints. This review highlights the present developments in resveratrol delivery techniques, including spray drying, liposomes, emulsions, and nanoencapsulation. Bioaccessibility, bioavailability, stability, and release of resveratrol from encapsulating matrices are discussed. Future research should focus on encapsulation approaches with high loading capacity, targeted delivery, and controlled release. In light of the growing interest in resveratrol and the increasing complexity of resveratrol-based formulations, review of current encapsulation methods is crucial to address existing limitations and pave the way for the development of next-generation delivery systems. This review discusses how the delivery systems with different structures and release mechanisms can unlock the full potential and benefits of resveratrol by enhancing its bioavailability and stability.
摘要：
由于其众多的生物活性，如抗氧化剂，抗炎,抗肿瘤，抗动脉粥样硬化，抗衰老,抗骨质疏松,抗肥胖,雌激素,神经保护和心脏保护作用，白藜芦醇作为一种有前途的生物活性物质，在食品和制药行业引起了广泛的关注。然而,在水介质中溶解度低，有限的生物利用度，白藜芦醇在恶劣环境中的低稳定性限制了其应用。对白藜芦醇包封作为克服所提到的应用限制的手段的研究的增长突出了对最近发展的总结的必要性。这篇综述重点介绍了白藜芦醇递送技术的最新发展。包括喷雾干燥，脂质体，乳液，和纳米封装。生物可及性，生物利用度，稳定性,并讨论了白藜芦醇从包封基质中的释放。未来的研究应集中在具有高负载能力的封装方法上，有针对性的交付，和控制释放。鉴于对白藜芦醇日益增长的兴趣和基于白藜芦醇的制剂日益复杂，审查当前的封装方法对于解决现有的局限性和为开发下一代递送系统铺平道路至关重要。这篇综述讨论了具有不同结构和释放机制的递送系统如何通过提高其生物利用度和稳定性来释放白藜芦醇的全部潜力和益处。
