Abstract：
OBJECTIVE: Carotid body tumours (CBTs) and baroreceptor failure (BRF) are two distinct but interrelated conditions, affecting the carotid body and its regulatory mechanisms. We aim to describe and quantify BRF after unilateral and bilateral CBT resections.
METHODS: Prospective cohort study. We included all patients with unilateral or bilateral CBT undergoing resection from April 2021 to January 2023. Demographics and CBTs characteristics were analysed; baroreceptor sensitivity assessment was conducted using the Composite Autonomic Severity Score (CASS). Statistical analyses were performed using R. Significance level was set at a 2-tailed α = 0.05.
RESULTS: A total of 30 patients with CBT underwent surgical resection, twenty-three were included in the study (18 unilateral and 5 bilateral CBTs). All 23 (100 %) were females, median age of 60 years. Regarding patients with unilateral CBT; preoperatively, 13 had BRF, the most common dysfunction subtype was mixed. Postoperatively, the most common dysfunction subtype was sympathetic failure. With regards to bilateral CBTs; 2 patients did not have autonomic dysfunction preoperatively. After bilateral surgical resection one patient remained without autonomic dysfunction; however, all other patients persisted with BRF.
CONCLUSIONS: BRF was present in 13 patients with unilateral CBT and 3 patients with bilateral tumours preoperatively; most will remain with BRF and will only change the characteristics postoperatively. No associations were found between type, severity of BRF and Shamblin classification or laterality. It is paramount that research in this area continues as many features are yet unknown regarding CBT pathogenesis, hence, BRF may be present yet not affect significantly quality of life.
METHODS: Prospective cohort study. We included all patients with unilateral or bilateral CBT undergoing resection from April 2021 to January 2023. Demographics and CBTs characteristics were analysed; baroreceptor sensitivity assessment was conducted using the Composite Autonomic Severity Score (CASS). Statistical analyses were performed using R. Significance level was set at a 2-tailed α = 0.05.
RESULTS: A total of 30 patients with CBT underwent surgical resection, twenty-three were included in the study (18 unilateral and 5 bilateral CBTs). All 23 (100 %) were females, median age of 60 years. Regarding patients with unilateral CBT; preoperatively, 13 had BRF, the most common dysfunction subtype was mixed. Postoperatively, the most common dysfunction subtype was sympathetic failure. With regards to bilateral CBTs; 2 patients did not have autonomic dysfunction preoperatively. After bilateral surgical resection one patient remained without autonomic dysfunction; however, all other patients persisted with BRF.
CONCLUSIONS: BRF was present in 13 patients with unilateral CBT and 3 patients with bilateral tumours preoperatively; most will remain with BRF and will only change the characteristics postoperatively. No associations were found between type, severity of BRF and Shamblin classification or laterality. It is paramount that research in this area continues as many features are yet unknown regarding CBT pathogenesis, hence, BRF may be present yet not affect significantly quality of life.
摘要：
目的：颈动脉体肿瘤（CBT）和压力感受器功能衰竭（BRF）是两种不同但相互关联的疾病，影响颈动脉体及其调节机制。我们旨在描述和量化单侧和双侧CBT切除后的BRF。
方法：前瞻性队列研究。我们纳入了2021年4月至2023年1月接受切除的所有单侧或双侧CBT患者。分析了人口统计学和CBT特征；使用复合自主神经严重程度评分（CASS）进行压力感受器敏感性评估。使用R进行统计分析。显著性水平设定为2尾α=0.05。
结果：共有30例CBT患者接受了手术切除，23例纳入研究(18例单侧CBT和5例双侧CBT).所有23人（100%）都是女性，中位年龄60岁。关于单侧CBT患者；术前，13有BRF，最常见的功能障碍亚型为混合型.术后,最常见的功能障碍亚型是交感神经功能衰竭.关于双侧CBT；2例患者术前没有自主神经功能障碍。双侧手术切除后，一名患者没有自主神经功能障碍；然而，所有其他患者坚持使用BRF.
结论：术前13例单侧CBT患者和3例双侧肿瘤患者存在BRF；大多数将保留BRF，并且仅在术后改变特征。没有发现类型之间的关联，BRF和Shamblin分类或侧向性的严重性。至关重要的是，在这一领域的研究仍在继续，因为许多关于CBT发病机制的特征尚不清楚，因此，BRF可能存在，但不会显著影响生活质量。
方法：前瞻性队列研究。我们纳入了2021年4月至2023年1月接受切除的所有单侧或双侧CBT患者。分析了人口统计学和CBT特征；使用复合自主神经严重程度评分（CASS）进行压力感受器敏感性评估。使用R进行统计分析。显著性水平设定为2尾α=0.05。
结果：共有30例CBT患者接受了手术切除，23例纳入研究(18例单侧CBT和5例双侧CBT).所有23人（100%）都是女性，中位年龄60岁。关于单侧CBT患者；术前，13有BRF，最常见的功能障碍亚型为混合型.术后,最常见的功能障碍亚型是交感神经功能衰竭.关于双侧CBT；2例患者术前没有自主神经功能障碍。双侧手术切除后，一名患者没有自主神经功能障碍；然而，所有其他患者坚持使用BRF.
结论：术前13例单侧CBT患者和3例双侧肿瘤患者存在BRF；大多数将保留BRF，并且仅在术后改变特征。没有发现类型之间的关联，BRF和Shamblin分类或侧向性的严重性。至关重要的是，在这一领域的研究仍在继续，因为许多关于CBT发病机制的特征尚不清楚，因此，BRF可能存在，但不会显著影响生活质量。
