Abstract：
Emulsion-based delivery systems are extensively employed for encapsulating functional active ingredients, protecting them from degradation, and enhancing bioavailability and release efficiency. Here, a CO2-responsive surfactant synthesized from rosin displays rapid responsiveness to CO2 at room temperature, transitioning reversibly switches between active and inactive states multiple times. The dual tertiary amines on the rosin rigid structure contributes to its CO2 sensitivity. When in its active cationic form, in conjunction with silica nanoparticles, it exhibits desired Pickering emulsification performance across various oil phases. In the Pickering emulsion loaded with quercetin, the encapsulation efficiency and loading efficiency reached 80.50% and 0.69%, respectively, with stability lasting at least 30 days. The system provides robust protection for quercetin against external factors, such as UV and heat, revealing sustained release effects. This study investigated the potential of using rosin-based CO2-responsive surfactants alongside nanoparticles to design stable Pickering emulsion systems for active substance encapsulation and sustained release.
摘要：
基于乳液的递送系统广泛用于包封功能性活性成分，保护它们免受退化，提高生物利用度和释放效率。这里,由松香合成的CO2响应表面活性剂在室温下对CO2具有快速响应性，转换可逆地在活动状态和非活动状态之间切换多次。松香刚性结构上的双叔胺有助于其CO2敏感性。当处于其活性阳离子形式时，与二氧化硅纳米粒子结合，它在各种油相中表现出期望的Pickering乳化性能。在装有槲皮素的皮克林乳液中，封装效率和装载效率分别达到80.50%和0.69%,分别,稳定性至少持续30天。该系统提供强大的保护槲皮素免受外部因素，如紫外线和热量，揭示持续释放效应。这项研究调查了使用松香基CO2响应表面活性剂与纳米粒子一起设计稳定的Pickering乳液系统以进行活性物质包封和持续释放的潜力。
