Abstract：
Notch-1 signaling plays a crucial role in stem cell maintenance and in repair mechanisms in various mucosal surfaces, including airway mucosa. Persistent injury can induce an aberrant activation of Notch-1 signaling in stem cells leading to an increased risk of cancer initiation and progression. Chronic inflammatory respiratory disorders, including Chronic Obstructive Pulmonary Disease (COPD) is associated to both over-activation of Notch-1 signaling and increased lung cancer risk. Increased oxidative stress, also due to cigarette smoke, can further contribute to promote cancer initiation and progression by amplifying inflammatory responses, by activating the Notch-1 signaling and by blocking regulatory mechanisms that inhibit the growth capacity of stem cells. This review offers a comprehensive overview on the effects of aberrant Notch-1 signaling activation in stem cells and of increased oxidative stress in the lung cancer. The putative role of natural compounds with anti-oxidant properties is also described.
摘要：
Notch-1信号在干细胞维持和各种粘膜表面的修复机制中起着至关重要的作用。包括气道粘膜。持续损伤可诱导干细胞中Notch-1信号传导的异常激活,导致癌症起始和进展的风险增加。慢性炎症性呼吸系统疾病，包括慢性阻塞性肺疾病(COPD)与Notch-1信号的过度激活和肺癌风险的增加有关.氧化应激增加，也由于香烟烟雾，可以通过放大炎症反应进一步促进癌症的发生和进展，通过激活Notch-1信号传导和阻断抑制干细胞生长能力的调节机制。这篇综述提供了关于肺癌中干细胞中异常Notch-1信号激活和氧化应激增加的影响的全面概述。还描述了具有抗氧化性质的天然化合物的推定作用。
