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Abstract：
OBJECTIVE: To confirm if the CYP17A1 gene regulates the ratio of T/E leading to MetS-BPH.
METHODS: 824 men, aged 47-88 years, were recruited into this study through consecutive routine physical examination programs and long-term outpatient screening. Several parameters, including SNPs of CYP17A1 gene, total testosterone, estradiol, and the ratio of total testosterone to estradiol (T/E) were obtained for each participant. Based on the diagnosis of BPH, MetS, and MetS-BPH, the participants were divided into BPH and non-BPH groups, MetS and non-MetS groups, and MetS-BPH and non-MetS-BPH groups. Values of the obtained parameters were evaluated using one-way analysis of variance, Student\'s t-test, Chi-squared test, and logistic regression analysis.
RESULTS: SNPs of the CYP17A1 gene, including the rs743572 genotypes (GG, GA, and AA), rs3781287 genotypes (GG, GT, TT), and rs4919686 genotypes (CC, CA, and AA), were present in every group. Only the GG genotype of rs743572 was independently associated with BPH (OR = 5.868, 95% CI: 3.363-7.974, P < 0.001), MetS (OR = 7.228, 95% CI: 3.925-11.331, P < 0.001), and MetS-BPH (OR = 3.417, 95% CI: 1.783-5.266, P < 0.001) after adjusting for age. In the population of genotype GG of rs743572, the decrease in T/E ratio was an independent risk factor for BPH (OR = 839.756, 95% CI: 36.978-1334.263, P = 0.001), MetS (OR = 376.988, 95% CI: 12.980-488.976, P < 0.003), and MetS-BPH (OR = 388.236, 95% CI: 24.869-495.363, P = 0.003).
CONCLUSIONS: The GG genotype of rs743572 in CYP17A1 gene regulating the decrease of T/E ratio can be an independent risk factor for MetS-BPH populations.
BACKGROUND: ChiCTR2200057632 \"retrospectively registered\".
UNASSIGNED: March 15, 2022 \"retrospectively registered\".
METHODS: 824 men, aged 47-88 years, were recruited into this study through consecutive routine physical examination programs and long-term outpatient screening. Several parameters, including SNPs of CYP17A1 gene, total testosterone, estradiol, and the ratio of total testosterone to estradiol (T/E) were obtained for each participant. Based on the diagnosis of BPH, MetS, and MetS-BPH, the participants were divided into BPH and non-BPH groups, MetS and non-MetS groups, and MetS-BPH and non-MetS-BPH groups. Values of the obtained parameters were evaluated using one-way analysis of variance, Student\'s t-test, Chi-squared test, and logistic regression analysis.
RESULTS: SNPs of the CYP17A1 gene, including the rs743572 genotypes (GG, GA, and AA), rs3781287 genotypes (GG, GT, TT), and rs4919686 genotypes (CC, CA, and AA), were present in every group. Only the GG genotype of rs743572 was independently associated with BPH (OR = 5.868, 95% CI: 3.363-7.974, P < 0.001), MetS (OR = 7.228, 95% CI: 3.925-11.331, P < 0.001), and MetS-BPH (OR = 3.417, 95% CI: 1.783-5.266, P < 0.001) after adjusting for age. In the population of genotype GG of rs743572, the decrease in T/E ratio was an independent risk factor for BPH (OR = 839.756, 95% CI: 36.978-1334.263, P = 0.001), MetS (OR = 376.988, 95% CI: 12.980-488.976, P < 0.003), and MetS-BPH (OR = 388.236, 95% CI: 24.869-495.363, P = 0.003).
CONCLUSIONS: The GG genotype of rs743572 in CYP17A1 gene regulating the decrease of T/E ratio can be an independent risk factor for MetS-BPH populations.
BACKGROUND: ChiCTR2200057632 \"retrospectively registered\".
UNASSIGNED: March 15, 2022 \"retrospectively registered\".
摘要：
目的：确认CYP17A1基因是否调节导致MetS-BPH的T/E比值。
方法：824名男性，47-88岁,通过连续的常规体检计划和长期门诊筛查被招募到这项研究中。几个参数，包括CYP17A1基因的SNPs,总睾酮,雌二醇,并获得每个参与者的总睾酮与雌二醇的比率(T/E)。根据BPH的诊断，MetS,还有MetS-BPH,参与者分为BPH和非BPH组，MetS和非MetS组，以及MetS-BPH和非MetS-BPH组。使用单向方差分析评估获得的参数值，学生t检验，卡方检验,和逻辑回归分析。
结果：CYP17A1基因的SNP，包括rs743572基因型(GG，GA,和AA），rs3781287基因型（GG，GT,TT),和rs4919686基因型(CC，CA,和AA），出现在每个小组中。只有rs743572的GG基因型与BPH独立相关(OR=5.868,95%CI:3.363-7.974,P<0.001),MetS（OR=7.228，95%CI：3.925-11.331，P<0.001），和MetS-BPH（OR=3.417，95％CI：1.783-5.266，P<0.001）。在rs743572基因型GG人群中,T/E比值降低是BPH的独立危险因素(OR=839.756,95%CI:36.978-1334.263,P=0.001),MetS（OR=376.988，95%CI：12.980-488.976，P<0.003），和MetS-BPH（OR=388.236，95%CI：24.869-495.363，P=0.003）。
结论：CYP17A1基因rs743572调节T/E比值降低的GG基因型可能是MetS-BPH人群的独立危险因素。
背景：ChiCTR2200057632\“回顾性注册\”。
■2022年3月15日“追溯注册”。
方法：824名男性，47-88岁,通过连续的常规体检计划和长期门诊筛查被招募到这项研究中。几个参数，包括CYP17A1基因的SNPs,总睾酮,雌二醇,并获得每个参与者的总睾酮与雌二醇的比率(T/E)。根据BPH的诊断，MetS,还有MetS-BPH,参与者分为BPH和非BPH组，MetS和非MetS组，以及MetS-BPH和非MetS-BPH组。使用单向方差分析评估获得的参数值，学生t检验，卡方检验,和逻辑回归分析。
结果：CYP17A1基因的SNP，包括rs743572基因型(GG，GA,和AA），rs3781287基因型（GG，GT,TT),和rs4919686基因型(CC，CA,和AA），出现在每个小组中。只有rs743572的GG基因型与BPH独立相关(OR=5.868,95%CI:3.363-7.974,P<0.001),MetS（OR=7.228，95%CI：3.925-11.331，P<0.001），和MetS-BPH（OR=3.417，95％CI：1.783-5.266，P<0.001）。在rs743572基因型GG人群中,T/E比值降低是BPH的独立危险因素(OR=839.756,95%CI:36.978-1334.263,P=0.001),MetS（OR=376.988，95%CI：12.980-488.976，P<0.003），和MetS-BPH（OR=388.236，95%CI：24.869-495.363，P=0.003）。
结论：CYP17A1基因rs743572调节T/E比值降低的GG基因型可能是MetS-BPH人群的独立危险因素。
背景：ChiCTR2200057632\“回顾性注册\”。
■2022年3月15日“追溯注册”。
