Abstract：
The term \'hyperkeratotic flexural erythema\' (HFE) has been used synonymously with granular parakeratosis (GP), to describe a scaly, typically intertriginous rash associated with contact factors such as benzalkonium chloride. However, clinical HFE can occur without the classical GP histological pattern. We reviewed skin biopsies from 10 patients with clinically diagnosed HFE. A progression of histopathological features is suggested. The absence of histological GP should not exclude the clinical diagnosis of HFE when there is a high index of suspicion.
摘要：
术语“过度角化弯曲性红斑”（HFE）已与颗粒状角化不全（GP）同义使用，为了描述鳞片状，通常与接触因素如苯扎氯铵有关的三性皮疹。然而,临床HFE可以在没有经典GP组织学模式的情况下发生。我们回顾了10例临床诊断为HFE的患者的皮肤活检。建议组织病理学特征的进展。当怀疑指数较高时，不应排除组织学GP的存在，不应排除HFE的临床诊断。
