PDF(Pubmed)
Abstract：
UNASSIGNED: Sclerocarya birrea (A. Rich). Hochst, popularly known as Morula, is a plant in the Anacardiaceae family. The bark, fruits, and leaves have traditionally been used to manage a variety of health conditions, most especially diabetes. Unfortunately, there is a scarcity of data and publications on the toxicity and safety of this plant.
UNASSIGNED: The current study was designed to assess the acute and chronic toxicity of a hydro-ethanolic extract of Sclerocarya birrea in albino rats.
UNASSIGNED: Sclerocarya birrea was extracted using an 80-20% hydro-ethanolic solution. For the acute toxicity study, female Wistar albino rats were treated with hydro-ethanolic leaf extract at a dose of 5000 mg/kg body weight and followed-up for 14 days. In the chronic toxicity study, 40 healthy Wistar albino rats were divided in 4 groups. The three treatment groups were administered the leaf hydro-ethanolic extract orally at dosages of 30, 150, and 1000 mg/kg once day for 90 days and the fourth group was a control group. Body and organs weights, haematological, serum biochemical, and histopathological parameters were measured at the end of the experiment.
UNASSIGNED: Single-dose oral administration of hydro-ethanolic leaf extract of Sclerocarya birrea at 5000 mg/kg produced no mortality indicating the LD50 is greater than 5000 mg/kg body weight. Following 90 days of administration of a hydro-ethanolic extract of Sclerocarya birrea leaves, there was no significant change in body and organs weights. Furthermore, biochemical, haematological and histopathological parameters did not vary significantly.
UNASSIGNED: This data indicates neither acute or chronic toxicity in rats and is consistent with the widespread and long-term usage of Sclerocarya birrea in African traditional medicine.
UNASSIGNED: The current study was designed to assess the acute and chronic toxicity of a hydro-ethanolic extract of Sclerocarya birrea in albino rats.
UNASSIGNED: Sclerocarya birrea was extracted using an 80-20% hydro-ethanolic solution. For the acute toxicity study, female Wistar albino rats were treated with hydro-ethanolic leaf extract at a dose of 5000 mg/kg body weight and followed-up for 14 days. In the chronic toxicity study, 40 healthy Wistar albino rats were divided in 4 groups. The three treatment groups were administered the leaf hydro-ethanolic extract orally at dosages of 30, 150, and 1000 mg/kg once day for 90 days and the fourth group was a control group. Body and organs weights, haematological, serum biochemical, and histopathological parameters were measured at the end of the experiment.
UNASSIGNED: Single-dose oral administration of hydro-ethanolic leaf extract of Sclerocarya birrea at 5000 mg/kg produced no mortality indicating the LD50 is greater than 5000 mg/kg body weight. Following 90 days of administration of a hydro-ethanolic extract of Sclerocarya birrea leaves, there was no significant change in body and organs weights. Furthermore, biochemical, haematological and histopathological parameters did not vary significantly.
UNASSIGNED: This data indicates neither acute or chronic toxicity in rats and is consistent with the widespread and long-term usage of Sclerocarya birrea in African traditional medicine.
摘要：
■Sclerocaryabirrea（A.Rich).Hochst,俗称Morula,是Anacardiaceae家族中的一种植物。树皮，水果,叶子传统上被用来管理各种健康状况，尤其是糖尿病。不幸的是,缺乏有关该植物毒性和安全性的数据和出版物。
■本研究旨在评估白化病大鼠的硬果水乙醇提取物的急性和慢性毒性。
■使用80-20%的氢乙醇溶液提取鸟粪硬果。对于急性毒性研究，雌性Wistar白化病大鼠接受5000mg/kg体重的乙醇叶提取物治疗，并随访14天。在慢性毒性研究中，40只健康Wistar白化病大鼠随机分为4组。三个治疗组以30、150和1000mg/kg的剂量每天口服给予叶乙醇提取物,持续90天,第四组为对照组。身体和器官的重量，血液学，血清生化，并在实验结束时测量组织病理学参数。
■以5000mg/kg的单剂量口服给药鸟粪的水乙醇叶提取物没有产生死亡率,表明LD50大于5000mg/kg体重。在服用Screrocaryabirrea叶的乙醇提取物90天后，身体和器官重量没有显著变化。此外，生物化学，血液学和组织病理学参数没有显著差异.
■该数据表明在大鼠中既无急性也无慢性毒性，并且与非洲传统医学中广泛和长期使用的Sclerocaryabirrea一致。
■本研究旨在评估白化病大鼠的硬果水乙醇提取物的急性和慢性毒性。
■使用80-20%的氢乙醇溶液提取鸟粪硬果。对于急性毒性研究，雌性Wistar白化病大鼠接受5000mg/kg体重的乙醇叶提取物治疗，并随访14天。在慢性毒性研究中，40只健康Wistar白化病大鼠随机分为4组。三个治疗组以30、150和1000mg/kg的剂量每天口服给予叶乙醇提取物,持续90天,第四组为对照组。身体和器官的重量，血液学，血清生化，并在实验结束时测量组织病理学参数。
■以5000mg/kg的单剂量口服给药鸟粪的水乙醇叶提取物没有产生死亡率,表明LD50大于5000mg/kg体重。在服用Screrocaryabirrea叶的乙醇提取物90天后，身体和器官重量没有显著变化。此外，生物化学，血液学和组织病理学参数没有显著差异.
■该数据表明在大鼠中既无急性也无慢性毒性，并且与非洲传统医学中广泛和长期使用的Sclerocaryabirrea一致。
