PDF(Pubmed)
Abstract：
UNASSIGNED: To determine the causal correlations of lifestyle behaviours and body fat distribution on diabetic microvascular complications through a Mendelian Randomization (MR).
UNASSIGNED: Genetic variants significantly associated with lifestyle behaviours, abdominal obesity, generalized obesity and diabetic microvascular complications were extracted from the UK Biobank (UKB) and FinnGen. The inverse variance weighted (IVW) method was regarded as the primary method. The main results were presented in odds ratio (OR) per standard deviation (SD) increase, and a series of sensitivity analyses were also conducted to validate the stability of the results.
UNASSIGNED: There was a positive causal correlation between smoking and the development of diabetic retinopathy (OR = 1.16; 95%CI: 1.04-1.30; p = 0.01). All of the indicators representing abdominal obesity had a statistically significant causal association with diabetic microvascular complications. Concerning generalized obesity, there were significant causal associations of body mass index (BMI) on diabetic nephropathy (OR = 1.92; 95%CI: 1.58-2.33; p < 0.001), diabetic retinopathy (OR = 1.27; 95%CI: 1.15-1.40; p < 0.001), and diabetic neuropathy (OR = 2.60; 95%CI: 1.95-3.45; p < 0.001). Other indicators including leg fat mass (left), and arm fat mass (left) also had a significant positive causality with diabetic microvascular complications.
UNASSIGNED: Our findings suggested that smoking has a genetically causal association with the development of diabetic retinopathy rather than diabetic nephropathy and diabetic neuropathy. In addition, both abdominal obesity and generalized obesity are risk factors for diabetic microvascular complications. To note, abdominal obesity represented by waist circumference (WC) is the most significant risk factor.
UNASSIGNED: Genetic variants significantly associated with lifestyle behaviours, abdominal obesity, generalized obesity and diabetic microvascular complications were extracted from the UK Biobank (UKB) and FinnGen. The inverse variance weighted (IVW) method was regarded as the primary method. The main results were presented in odds ratio (OR) per standard deviation (SD) increase, and a series of sensitivity analyses were also conducted to validate the stability of the results.
UNASSIGNED: There was a positive causal correlation between smoking and the development of diabetic retinopathy (OR = 1.16; 95%CI: 1.04-1.30; p = 0.01). All of the indicators representing abdominal obesity had a statistically significant causal association with diabetic microvascular complications. Concerning generalized obesity, there were significant causal associations of body mass index (BMI) on diabetic nephropathy (OR = 1.92; 95%CI: 1.58-2.33; p < 0.001), diabetic retinopathy (OR = 1.27; 95%CI: 1.15-1.40; p < 0.001), and diabetic neuropathy (OR = 2.60; 95%CI: 1.95-3.45; p < 0.001). Other indicators including leg fat mass (left), and arm fat mass (left) also had a significant positive causality with diabetic microvascular complications.
UNASSIGNED: Our findings suggested that smoking has a genetically causal association with the development of diabetic retinopathy rather than diabetic nephropathy and diabetic neuropathy. In addition, both abdominal obesity and generalized obesity are risk factors for diabetic microvascular complications. To note, abdominal obesity represented by waist circumference (WC) is the most significant risk factor.
摘要：
■通过孟德尔随机化（MR）确定生活方式行为和体脂分布对糖尿病微血管并发症的因果关系。
■遗传变异与生活方式行为显著相关，腹部肥胖，从英国生物银行(UKB)和FinnGen中提取了全身性肥胖和糖尿病微血管并发症.逆方差加权(IVW)方法被认为是主要方法。主要结果以每标准差(SD)增加的比值比(OR)表示，并进行了一系列敏感性分析，以验证结果的稳定性。
■吸烟与糖尿病视网膜病变的发生呈正相关（OR=1.16；95CI：1.04-1.30；p=0.01）。所有代表腹部肥胖的指标都与糖尿病微血管并发症有统计学意义的因果关系。关于广泛性肥胖，体重指数（BMI）与糖尿病肾病之间存在显着因果关系（OR=1.92；95CI：1.58-2.33；p<0.001），糖尿病视网膜病变（OR=1.27；95CI：1.15-1.40；p<0.001），和糖尿病神经病变（OR=2.60；95CI：1.95-3.45；p<0.001）。其他指标包括腿部脂肪量（左），和手臂脂肪量(左)也与糖尿病微血管并发症有显著的正因果关系。
■我们的研究结果表明，吸烟与糖尿病视网膜病变的发生具有遗传因果关系，而不是糖尿病肾病和糖尿病神经病变。此外,腹型肥胖和全身型肥胖都是糖尿病微血管并发症的危险因素.要注意，以腰围（WC）为代表的腹部肥胖是最重要的危险因素。
■遗传变异与生活方式行为显著相关，腹部肥胖，从英国生物银行(UKB)和FinnGen中提取了全身性肥胖和糖尿病微血管并发症.逆方差加权(IVW)方法被认为是主要方法。主要结果以每标准差(SD)增加的比值比(OR)表示，并进行了一系列敏感性分析，以验证结果的稳定性。
■吸烟与糖尿病视网膜病变的发生呈正相关（OR=1.16；95CI：1.04-1.30；p=0.01）。所有代表腹部肥胖的指标都与糖尿病微血管并发症有统计学意义的因果关系。关于广泛性肥胖，体重指数（BMI）与糖尿病肾病之间存在显着因果关系（OR=1.92；95CI：1.58-2.33；p<0.001），糖尿病视网膜病变（OR=1.27；95CI：1.15-1.40；p<0.001），和糖尿病神经病变（OR=2.60；95CI：1.95-3.45；p<0.001）。其他指标包括腿部脂肪量（左），和手臂脂肪量(左)也与糖尿病微血管并发症有显著的正因果关系。
■我们的研究结果表明，吸烟与糖尿病视网膜病变的发生具有遗传因果关系，而不是糖尿病肾病和糖尿病神经病变。此外,腹型肥胖和全身型肥胖都是糖尿病微血管并发症的危险因素.要注意，以腰围（WC）为代表的腹部肥胖是最重要的危险因素。
