PDF(Pubmed)
Abstract：
Congenital microtia is the most common cause of auricular defects, with a prevalence of approximately 5.18 per 10,000 individuals. Autologous rib cartilage grafting is the leading treatment modality at this stage of auricular reconstruction currently. However, harvesting rib cartilage may lead to donor site injuries, such as pneumothorax, postoperative pain, chest wall scarring, and deformity. Therefore, in the pursuit of better graft materials, biomaterial scaffolds with great histocompatibility, precise control of morphology, non-invasiveness properties are gradually becoming a new research hotspot in auricular reconstruction. This review collectively presents the exploit and application of 3D printing biomaterial scaffold in auricular reconstruction. Although the tissue-engineered ear still faces challenges before it can be widely applied to patients in clinical settings, and its long-term effects have yet to be evaluated, we aim to provide guidance for future research directions in 3D printing biomaterial scaffold for auricular reconstruction. This will ultimately benefit the translational and clinical application of cartilage tissue engineering and biomaterials in the treatment of auricular defects.
摘要：
先天性小耳畸形是耳廓缺损的最常见原因，患病率约为每10,000个人5.18。自体肋软骨移植是目前耳廓重建这一阶段的主要治疗方式。然而,收获肋软骨可能导致供体部位受伤，如气胸，术后疼痛,胸壁疤痕,和畸形。因此,为了追求更好的移植材料，具有良好组织相容性的生物材料支架，形态的精确控制，无创伤特性逐渐成为耳廓重建新的研究热点。本文就3D打印生物材料支架在耳廓重建中的应用和开发作一综述。尽管组织工程耳在临床广泛应用于患者之前仍然面临挑战，其长期影响还有待评估，旨在为未来3D打印耳廓重建生物材料支架的研究方向提供指导。这将最终有利于软骨组织工程和生物材料在耳廓缺损治疗中的转化和临床应用。
