UNASSIGNED: We conducted a prospective cohort study of 49 ESRD patients who underwent KTx. Echocardiography was performed at baseline and at 3 months after KTx. LV end-diastolic volume, LV end-systolic volume, LV end-diastolic diameter, LV ejection fraction (LVEF), E/e\', maximum LA volume index (LAVi), LV global longitudinal strain (LVGLS), and all LA strain values, including booster (LASb), conduit (LAScd), and reservoir (LASr), improved significantly after KTx (P < 0.05). Regarding independent predictors of impaired LA and LV strains, pre-KTx values of LVEF, LAVi, and NT-proBNP were associated with LVGLS impairment after KTx; pre-KTx values of LAVi and LVEF were associated with LASr impairment after KTx.
UNASSIGNED: The present study provided valuable evidence on the effects of KTx on uraemic cardiomyopathy demonstrated by LA strain and LV strain improvements and indicated pre-KTx LVEF and LAVi as significant independent predictors of LVGLS and LASr impairment after KTx.
■我们对49例接受KTx的ESRD患者进行了前瞻性队列研究。在基线和KTx后3个月进行超声心动图检查。左心室舒张末期容积,左心室收缩末期容积,左心室舒张末期内径,左心室射血分数(LVEF),E/E\',最大LA体积指数(LAVi),低压全球纵向应变(LVGLS),和所有LA应变值,包括助推器(LASb),导管(LAScd),和水库(LASr),KTx治疗后明显改善(P<0.05)。关于受损LA和LV菌株的独立预测因子,LVEF的前KTx值,拉维,和NT-proBNP与KTx后的LVGLS损伤相关;LAVi和LVEF的前KTx值与KTx后的LASr损伤相关。
■本研究提供了有价值的证据,证明了KTx对尿毒症性心肌病的影响,并通过LA菌株和LV菌株的改善证明了KTx前LVEF和LAVi是KTx后LVGLS和LASr受损的重要独立预测因子。