PDF(Pubmed)
Abstract：
UNASSIGNED: Many patients with coronavirus disease-2019 (COVID-19), particularly from the pandemic\'s early phase, have been reported to have evidence of cardiac injury such as cardiac symptoms, troponinaemia, or imaging or ECG abnormalities during their acute course. Cardiac magnetic resonance (CMR) and transthoracic echocardiography (TTE) have been widely used to assess cardiac function and structure and characterize myocardial tissue during COVID-19 with report of numerous abnormalities. Overall, findings have varied, and long-term impact of COVID-19 on the heart needs further elucidation.
UNASSIGNED: We performed TTE and 3 T CMR in survivors of the initial stage of the pandemic without pre-existing cardiac disease and matched controls at long-term follow-up a median of 308 days after initial infection. Study population consisted of 40 COVID-19 survivors (50% female, 28% Black, and 48% Hispanic) and 12 controls of similar age, sex, and race-ethnicity distribution; 35% had been hospitalized with 28% intubated. We found no difference in echocardiographic characteristics including measures of left and right ventricular structure and systolic function, valvular abnormalities, or diastolic function. Using CMR, we also found no differences in measures of left and right ventricular structure and function and additionally found no significant differences in parameters of tissue structure including T1, T2, extracellular volume mapping, and late gadolinium enhancement. With analysis stratified by patient hospitalization status as an indicator of COVID-19 severity, no differences were uncovered.
UNASSIGNED: Multimodal imaging of a diverse cohort of COVID-19 survivors indicated no long-lasting damage or inflammation of the myocardium.
UNASSIGNED: We performed TTE and 3 T CMR in survivors of the initial stage of the pandemic without pre-existing cardiac disease and matched controls at long-term follow-up a median of 308 days after initial infection. Study population consisted of 40 COVID-19 survivors (50% female, 28% Black, and 48% Hispanic) and 12 controls of similar age, sex, and race-ethnicity distribution; 35% had been hospitalized with 28% intubated. We found no difference in echocardiographic characteristics including measures of left and right ventricular structure and systolic function, valvular abnormalities, or diastolic function. Using CMR, we also found no differences in measures of left and right ventricular structure and function and additionally found no significant differences in parameters of tissue structure including T1, T2, extracellular volume mapping, and late gadolinium enhancement. With analysis stratified by patient hospitalization status as an indicator of COVID-19 severity, no differences were uncovered.
UNASSIGNED: Multimodal imaging of a diverse cohort of COVID-19 survivors indicated no long-lasting damage or inflammation of the myocardium.
摘要：
■许多2019年冠状病毒病患者（COVID-19），特别是从大流行的早期阶段，据报道有心脏损伤的证据，如心脏症状，肌钙蛋白血症,或影像学或心电图异常在其急性过程中。心脏磁共振（CMR）和经胸超声心动图（TTE）已被广泛用于评估COVID-19期间的心脏功能和结构以及表征心肌组织，并有许多异常的报道。总的来说,调查结果各不相同，COVID-19对心脏的长期影响需要进一步阐明。
■我们在初次感染后中位308天的长期随访中，对没有预先存在心脏病的大流行初期幸存者和匹配的对照进行了TTE和3TCMR。研究人群包括40名COVID-19幸存者(50%为女性，28%黑色,和48％的西班牙裔）和12个年龄相似的对照，性别,和种族-种族分布;35%住院,28%插管.我们发现超声心动图特征没有差异，包括左右心室结构和收缩功能的测量，瓣膜异常,或舒张功能。使用CMR，我们还发现左、右心室结构和功能的测量没有差异，另外在组织结构参数（包括T1、T2、细胞外体积图）上也没有发现显著差异，和钆的后期增强。通过按患者住院状况分层分析作为COVID-19严重程度的指标，没有发现任何差异。
■对不同队列的COVID-19幸存者进行的多模态成像显示，心肌没有长期的损伤或炎症。
■我们在初次感染后中位308天的长期随访中，对没有预先存在心脏病的大流行初期幸存者和匹配的对照进行了TTE和3TCMR。研究人群包括40名COVID-19幸存者(50%为女性，28%黑色,和48％的西班牙裔）和12个年龄相似的对照，性别,和种族-种族分布;35%住院,28%插管.我们发现超声心动图特征没有差异，包括左右心室结构和收缩功能的测量，瓣膜异常,或舒张功能。使用CMR，我们还发现左、右心室结构和功能的测量没有差异，另外在组织结构参数（包括T1、T2、细胞外体积图）上也没有发现显著差异，和钆的后期增强。通过按患者住院状况分层分析作为COVID-19严重程度的指标，没有发现任何差异。
■对不同队列的COVID-19幸存者进行的多模态成像显示，心肌没有长期的损伤或炎症。
