UNASSIGNED: This will be an observational study conducted in the Department of Pathology, JNMC, Wardha (Sawangi). Radical mastectomy specimens will be studied for COX-2 expression by immunohistochemistry in patients diagnosed with breast carcinoma. COX-2 expression will be quantified as immunohistochemical score and results will be correlated with various histopathological parameters.
UNASSIGNED: The expected result of our study will suggest an association of COX-2 expression to the factors associated with poor prognosis in breast carcinoma. A positive correlation is expected between larger tumor size, positive lymph node status, higher T stage and N stage and lymphovascular invasion.
UNASSIGNED: Conclusions will be drawn from the obtained results of the immunohistochemical study by using COX-2- for detection of overexpression of COX-2 when evaluated with TNM staging, histological grading and molecular types of breast cancer.
■这将是在病理学系进行的一项观察性研究,JNMC,Wardha(Sawangi)。将通过免疫组织化学研究乳腺癌根治术标本中COX-2的表达。COX-2表达将定量为免疫组织化学评分,并且结果将与各种组织病理学参数相关联。
■我们研究的预期结果将表明COX-2表达与乳腺癌不良预后相关的因素有关。预计较大的肿瘤大小之间存在正相关,阳性淋巴结状态,较高的T期和N期和淋巴管浸润。
■当用TNM分期评估时,将通过使用COX-2检测COX-2过表达的免疫组织化学研究结果得出结论,乳腺癌的组织学分级和分子类型。