PDF(Pubmed)
Abstract：
Remitting seronegative symmetrical synovitis with pitting oedema is a rare rheumatological condition, predominating in the elderly male. It is characterised by the abrupt onset of marked pitting oedema, symmetrical distal synovitis, absence of rheumatoid factor and an excellent response to glucocorticoids. RS3PE may be the harbinger of a malignancy so the diagnosis should prompt evaluation and exclusion of such condition; in these cases, the response to glucocorticoids is only partial and treating the neoplasia is essential. The differential diagnosis includes late-onset rheumatoid arthritis, polymyalgia rheumatica and calcium pyrophosphate crystal-related arthritis. We present the case of a patient with remitting seronegative symmetrical synovitis with pitting oedema associated with clear cell renal cell carcinoma.
摘要：
缓解性血清阴性对称性滑膜炎伴凹陷性水肿是一种罕见的风湿病，以老年男性为主。它的特点是突然出现明显的凹陷性水肿，对称性远端滑膜炎,缺乏类风湿因子和对糖皮质激素的良好反应。RS3PE可能是恶性肿瘤的先兆，因此诊断应迅速评估和排除此类疾病；在这些情况下，对糖皮质激素的反应仅是部分的，治疗瘤形成至关重要。鉴别诊断包括迟发性类风湿关节炎，风湿性多肌痛和焦磷酸钙晶体相关关节炎。我们介绍了一例缓解血清阴性对称性滑膜炎伴与透明细胞肾细胞癌相关的凹陷性水肿的患者。
