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Abstract：
Objective This study aims to identify factors associated with mosaicism in human embryos at Hung Vuong Hospital. Methods We performed a retrospective analysis of data from 2018 to 2022, approved by the Hung Vuong Hospital Ethics Committee (CS/HV/23/15). We analyzed variables such as demographic characteristics, clinical measurements, and in-vitro fertilization (IVF) cycle outcomes to investigate their relationship with embryo mosaicism. Results A total of 73 couples undergoing IVF with preimplantation genetic testing (PGT) were included in the analysis. Among 308 embryos, 98 (31.8%) were mosaic, 124 (40.3%) were euploid, and 86 (27.9%) were aneuploid. Univariable analysis revealed that female age was significantly associated with increased odds of mosaicism (odd ratio (OR) = 1.11, 95% confidence interval (CI): 1.04 - 1.19, p = 0.003). Male age demonstrated a marginal association with mosaicism (OR = 1.05, 95% CI: 1.00 - 1.11, p = 0.07). Other factors, including body mass index (BMI), anti-Mullerian hormone (AMH) levels, blood types, and sperm quality, were not significantly associated with mosaicism. In the multivariable analysis, controlling for both female and male age, female age showed a trend toward significance (OR = 1.12, 95% CI: 1.02 - 1.23, p = 0.02), while male age showed no significant effect (OR = 0.99, 95% CI: 0.92 - 1.06, p = 0.75). Conclusions The findings suggest that female age is a critical factor influencing the occurrence of mosaicism in embryos. Further research is needed to fully understand the mechanisms underlying mosaicism in human embryos.
摘要：
目的探讨洪武医院胚胎镶嵌的相关因素。方法回顾性分析2018年至2022年的数据,并经洪富丰医院伦理委员会(CS/HV/23/15)批准。我们分析了人口统计学特征等变量，临床测量，和体外受精（IVF）周期结局，以探讨它们与胚胎镶嵌性的关系。结果共有73对接受试管婴儿植入前基因检测(PGT)的夫妇被纳入分析。在308个胚胎中，98（31.8％）是马赛克，124（40.3%）为整倍体，86（27.9%）为非整倍体。单变量分析显示，女性年龄与镶嵌几率增加显著相关（奇数比（OR）=1.11，95%置信区间（CI）：1.04-1.19，p=0.003）。男性年龄与镶嵌性相关（OR=1.05，95％CI：1.00-1.11，p=0.07）。其他因素,包括体重指数（BMI），抗苗勒管激素（AMH）水平，血型,精子质量，与镶嵌性无关。在多变量分析中，控制女性和男性的年龄，女性年龄呈显著性趋势(OR=1.12，95%CI：1.02-1.23，p=0.02)，而男性年龄无显著影响(OR=0.99,95%CI:0.92-1.06,p=0.75)。结论女性年龄是影响胚胎镶嵌发生的关键因素。需要进一步的研究来充分了解人类胚胎镶嵌的潜在机制。
