Abstract：
Over the past few decades, there have been advancements in the development of high-performance tissue adhesives as alternatives to traditional sutures and staples for rapid and effective wound closure post-surgery. While tissue adhesives offer advantages such as ease of use, short application time, and minimal tissue damage, they also face challenges related to biocompatibility, biodegradability, and adhesive strength. In this study, L-lysine diisocyanate (LDI) and trimethylolpropane (TMP) were utilized as the primary raw materials to produce a prepolymer terminated with NCO, resulting in the development of a new biocompatible polyurethane tissue adhesive (TMP-LDI). Additionally, SiO2 nanoparticles were incorporated into the prepolymer, significantly enhancing the adhesive strength of the TMP-LDI tissue adhesive through the \"nanobridging effect,\" achieving a strength of 170.4 kPa. Furthermore, the SiO2/TMP-LDI tissue adhesive exhibited satisfactory temperature change during curing and degradation performance. In vitro and in vivo studies demonstrated that SiO2/TMP-LDI exhibited good biocompatibility, efficient hemostasis, antimicrobial properties, and the ability to promote wound healing. This research presents a novel approach for the development of tissue adhesives with superior adhesive performance.
摘要：
在过去的几十年里，在开发高性能组织粘合剂作为传统缝合线和U形钉的替代品方面取得了进展，用于术后快速有效的伤口闭合。虽然组织粘合剂具有易于使用等优点，短的应用时间，和最小的组织损伤，他们还面临着与生物相容性有关的挑战，生物降解性，和粘合强度。在这项研究中,以L-赖氨酸二异氰酸酯（LDI）和三羟甲基丙烷（TMP）为主要原料，生产以NCO封端的预聚物，导致一种新的生物相容性聚氨酯组织粘合剂（TMP-LDI）的开发。此外,将SiO2纳米颗粒掺入预聚物中，通过“纳米网格效应”显着提高TMP-LDI组织粘合剂的粘合强度，“达到170.4kPa的强度。此外，SiO2/TMP-LDI组织粘合剂在固化和降解性能期间表现出令人满意的温度变化。体外和体内研究表明，SiO2/TMP-LDI表现出良好的生物相容性，有效止血，抗菌性能，以及促进伤口愈合的能力。这项研究为开发具有优异粘合性能的组织粘合剂提供了一种新颖的方法。
