靶向 FGFR4 和 CD276 的 CAR - T 细胞同时显示出对儿童横纹肌肉瘤的有效抗肿瘤作用。
Mesh : Receptor, Fibroblast Growth Factor, Type 4 / metabolism genetics Rhabdomyosarcoma / therapy immunology genetics Humans Animals Receptors, Chimeric Antigen / immunology metabolism Cell Line, Tumor Xenograft Model Antitumor Assays Mice Immunotherapy, Adoptive / methods B7 Antigens / metabolism immunology genetics MyoD Protein / metabolism genetics T-Lymphocytes / immunology metabolism Child Female Mice, SCID Mice, Inbred NOD
来 源:
DOI:10.1038/s41467-024-50251-x
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