PDF(Pubmed)
Abstract：
A globally implemented unified phylogenetic classification for human respiratory syncytial virus (HRSV) below the subgroup level remains elusive. We formulated global consensus of HRSV classification on the basis of the challenges and limitations of our previous proposals and the future of genomic surveillance. From a high-quality curated dataset of 1,480 HRSV-A and 1,385 HRSV-B genomes submitted to GenBank and GISAID (https://www.gisaid.org) public sequence databases through March 2023, we categorized HRSV-A/B sequences into lineages based on phylogenetic clades and amino acid markers. We defined 24 lineages within HRSV-A and 16 within HRSV-B and provided guidelines for defining prospective lineages. Our classification demonstrated robustness in its applicability to both complete and partial genomes. We envision that this unified HRSV classification proposal will strengthen HRSV molecular epidemiology on a global scale.
摘要：
全球实施的低于亚组水平的人类呼吸道合胞病毒（HRSV）的统一系统发育分类仍然难以捉摸。我们基于我们先前的提议的挑战和局限性以及基因组监测的未来，制定了HRSV分类的全球共识。来自提交给GenBank和GISAID的1,480HRSV-A和1,385HRSV-B基因组的高质量精选数据集（https://www.gisaid.org）到2023年3月为止的公共序列数据库，我们根据系统进化枝和氨基酸标记将HRSV-A/B序列分类为谱系。我们在HRSV-A中定义了24个谱系，在HRSV-B中定义了16个谱系，并提供了定义预期谱系的指南。我们的分类证明了其对完整和部分基因组的适用性。我们设想这一统一的HRSV分类提案将在全球范围内加强HRSV分子流行病学。
