PDF(Pubmed)
Abstract：
Archaea represent a separate domain of life, next to bacteria and eukarya. As components of the human microbiome, archaea have been associated with various diseases, including periodontitis, endodontic infections, small intestinal bacterial overgrowth, and urogenital tract infections. Archaea are generally considered nonpathogenic; the reasons are speculative because of limited knowledge and gene annotation challenges. Nevertheless, archaeal syntrophic principles that shape global microbial networks aid both archaea and potentially pathogenic bacteria. Evaluating archaea interactions remains challenging, requiring clinical studies on inflammatory potential and the effects of archaeal metabolism. Establishing a culture collection is crucial for investigating archaea functions within the human microbiome, which could improve health outcomes in infectious diseases. We summarize potential reasons for archaeal nonpathogenicity, assess the association with infectious diseases in humans, and discuss the necessary experimental steps to enable mechanistic studies involving archaea.
摘要：
古细菌代表了一个独立的生命领域，在细菌和真核生物旁边。作为人类微生物组的组成部分，古细菌与各种疾病相关，包括牙周炎,牙髓感染,小肠细菌过度生长，和泌尿生殖道感染.古菌通常被认为是非致病性的；由于知识有限和基因注释挑战，原因是推测性的。然而，形成全球微生物网络的古细菌共生原理对古细菌和潜在致病细菌都有帮助。评估古细菌的相互作用仍然具有挑战性，需要对炎症潜力和古细菌代谢的影响进行临床研究。建立培养物集合对于研究人类微生物组中的古细菌功能至关重要，这可以改善传染病的健康结果。我们总结了古细菌非致病性的潜在原因，评估与人类传染病的关系，并讨论必要的实验步骤，以实现涉及古细菌的机械研究。
