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Abstract：
The purpose of this study was to evaluate the quantitative computed tomography (CT) volumetry and densitometry and in pediatric patients with pectus excavatum (PE). We measured pectus index (PI) and separated inspiratory and expiratory lung volumes and densities. We obtained the total lung volume (TLV) and mean lung density (MLD) during inspiration and expiration, and the ratio of end expiratory to inspiratory volume (E/I volume) and MLD (E/I density) were calculated. The difference between inspiratory and end expiratory volume (I-E volume) and MLD (I-E density) were also calculated. A total of 199 patients, including 164 PE patients and 35 controls, were included in this study. The result shows that the PE group had lower inspiratory TLV (mean, 2670.76±1364.22 ml) than the control group (3219.57±1313.87 ml; p = 0.027). In the PE group, the inspiratory (-787.21±52.27 HU vs. -804.94±63.3 HU) and expiratory MLD (-704.51±55.41 HU vs. -675.83±64.62 HU) were significantly lower than the indices obtained from the control group (p = 0.006). In addition, significantly lower values of TLV and MLD difference and higher value of TLV and MLD ratio were found in the PE group (p <0.0001). PE patients were divided into severe vs. mild groups based on the PI cutoff value of 3.5. The inspiratory MLD and TLV ratio in the severe PE group were lower than those in the mild PE group, respectively (p <0.05). In conclusion, quantitative pulmonary evaluation through CT in pediatric PE patients may provide further information in assessing the functional changes in lung parenchyma as a result of chest wall deformity.
摘要：
这项研究的目的是评估定量计算机断层扫描（CT）容积和密度测定以及漏斗胸（PE）的儿科患者。我们测量了胸肌指数（PI），并分离了吸气和呼气肺的体积和密度。我们获得了吸气和呼气期间的总肺容积（TLV）和平均肺密度（MLD），计算呼气末与吸气量的比值(E/I容积)和MLD(E/I密度)。还计算了吸气和呼气末容积（I-E容积）和MLD（I-E密度）之间的差异。共199名患者，包括164名PE患者和35名对照，包括在这项研究中。结果表明，PE组有较低的吸气TLV(平均，2670.76±1364.22ml)比对照组(3219.57±1313.87ml;p=0.027)。在PE组,吸气(-787.21±52.27HUvs.-804.94±63.3HU）和呼气MLD（-704.51±55.41HUvs.-675.83±64.62HU）显着低于从对照组获得的指数（p=0.006）。此外,在PE组中发现TLV和MLD差异值显着降低，而TLV和MLD比率值较高（p<0.0001）。PE患者分为严重vs.轻度组基于3.5的PI截止值。重度PE组吸气MLD和TLV比值低于轻度PE组,分别为(p<0.05)。总之,通过CT对小儿PE患者进行定量肺功能评估可能为评估胸壁畸形导致的肺实质功能变化提供更多信息。
