Abstract：
Oligodendrocyte precursor cells (OPCs) are a heterogeneous multipotent population in the central nervous system (CNS) that appear during embryogenesis and persist as resident cells in the adult brain parenchyma. OPCs could generate oligodendrocytes to participate in myelination. Recent advances have renewed our knowledge of OPC biology by discovering novel markers of oligodendroglial cells, the myelin-independent roles of OPCs, and the regulatory mechanism of OPC development. In this review, we will explore the updated knowledge on OPC identity, their multifaceted roles in the CNS in health and diseases, as well as the regulatory mechanisms that are involved in their developmental stages, which hopefully would contribute to a further understanding of OPCs and attract attention in the field of OPC biology.
摘要：
少突胶质前体细胞（OPCs）是中枢神经系统（CNS）中的异质多能细胞，在胚胎发生过程中出现，并在成年脑实质中作为常驻细胞存在。OPCs可以产生少突胶质细胞参与髓鞘形成。最近的进展通过发现少突胶质细胞的新标记，更新了我们对OPC生物学的认识。OPCs的髓磷脂非依赖性作用，以及OPC发展的调控机制。在这次审查中,我们将探索有关OPC身份的最新知识，它们在中枢神经系统中在健康和疾病中的多方面作用，以及涉及其发展阶段的监管机制，这有望有助于进一步了解OPC并引起OPC生物学领域的关注。
