Abstract:
Galectins, a family of glycan-binding proteins have been shown to bind a wide range of glycans. In the cytoplasm, these glycans can be endogenous (or \"self\"), originating from damaged endocytic vesicles, or exogenous (or \"non-self\"), found on the surface of invading microbial pathogens. Galectins can detect these unusual cytosolic exposures to glycans and serve as critical regulators in orchestrating immune responses in innate and adaptive immunity. This review provides an overview of how galectins modulate host cellular responses, such as autophagy, xenophagy, and inflammasome-dependent cell death program, to infection.
摘要:
Galectins,一个聚糖结合蛋白家族已经显示出结合多种聚糖。在细胞质中,这些聚糖可以是内源性的(或“自我”),源自受损的内吞小泡,或外生(或“非自我”),在入侵微生物病原体的表面发现。Galectins可以检测这些不寻常的细胞溶质对聚糖的暴露,并在先天和适应性免疫中协调免疫反应中充当关键调节剂。这篇综述概述了半乳糖凝集素如何调节宿主细胞反应,比如自噬,异种吞噬,和依赖炎性体的细胞死亡程序,感染。