METHODS: This was an observational, longitudinal, retrospective, and bicentric study. It included adult patients admitted to two hospitals in Málaga, Spain (2014-2018). The minimum follow-up period was 2 years or until death.
RESULTS: A total of 154 patients were included; the majority (71.4%) were admitted to the internal medicine department. The median follow-up was 3.5 weeks (interquartile range [IQR] 1.1-11.5). The mean (standard deviation) age was 67.6 (12.3) years, with a predominance of males (58.4%). The median (IQR) serum calcium at admission was 13.2 (11.8-14.6) mg/dl. The most common neoplasms were pulmonary (27.3%), hematologic (23.4%), urological (13%), and breast (12.3%). Furthermore, 56.5% of cases had a known history of neoplasia at the time of diagnosis. The parathyroid hormone (PTH) level was determined in 24%; of these, 10.8% had elevated levels. In all, 95.5% of patients died during follow-up. The median survival was 3.4 weeks (95% confidence interval 2.6-4.3). Factors associated with higher mortality were age, serum calcium at admission, previous history of neoplasia, etiology other than multiple myeloma, and noncorrection of hypercalcemia.
CONCLUSIONS: In hospitalized patients, paraneoplastic hypercalcemia was associated with high short-term mortality. Several factors associated with a worse prognosis were identified in these patients.
方法:这是一个观察性的,纵向,回顾性,和双中心研究。其中包括马拉加两家医院收治的成年患者,西班牙(2014-2018)。最短随访期为2年或直至死亡。
结果:共纳入154例患者;大多数(71.4%)进入内科。中位随访时间为3.5周(四分位距[IQR]1.1-11.5)。平均(标准差)年龄为67.6(12.3)岁,以男性为主(58.4%)。入院时血清钙中位数(IQR)为13.2(11.8-14.6)mg/dl。最常见的肿瘤是肺(27.3%),血液学(23.4%),泌尿外科(13%),和乳房(12.3%)。此外,56.5%的病例在诊断时具有已知的肿瘤病史。甲状旁腺激素(PTH)水平测定为24%;其中,10.8%的水平升高。总之,95.5%的患者在随访期间死亡。中位生存期为3.4周(95%置信区间2.6-4.3)。与较高死亡率相关的因素是年龄,入院时血清钙,以前的肿瘤病史,多发性骨髓瘤以外的病因,和未纠正高钙血症。
结论:在住院患者中,副肿瘤性高钙血症与高短期死亡率相关.在这些患者中发现了与预后较差相关的几个因素。