METHODS: Cross-sectional study.
METHODS: Two masked retinal experts evaluated the presence of the TLS in eyes with NE-MNV and controls with an RPE elevation without exudation due to other causes than NE-MNV in AMD [e.g., medium-large drusen, cuticular drusen, basal laminar deposits (BlamD)].
RESULTS: 130 eyes of 98 consecutive patients met the study criteria; 40 eyes of 40 patients satisfied the criteria for being included in the NE-MNV secondary to AMD group (27 females, 13 males, with a mean age of 73.8 ± 8.0 years), and 90 eyes of 58 patients met the criteria to be included in the control group (31 eyes were included in the medium-to-large drusen sub-group, 32 eyes in the cuticular drusen sub-group, and 27 eyes in the BlamD group. The TLS was observed in 39/40 patients with NE-MNV and 8/90 controls. The sensitivity and specificity of the TLS for the diagnosis of NE-MNV were 97% and 91%, respectively.
CONCLUSIONS: The TLS on OCT demonstrated high sensitivity and specificity values in detecting treatment-naive type 1 NE-MNV.
方法:横断面研究。
方法:两名蒙面视网膜专家评估了患有NE-MNV的眼睛和患有RPE升高的对照者中TLS的存在,而没有由于NE-MNV以外的其他原因导致的渗出[例如,中型玻璃疣,角质层玻璃疣,基底层状沉积物(BlamD)]。
结果:连续98例患者的130只眼符合研究标准;40例患者的40只眼符合纳入NE-MNV继发AMD组的标准(27例女性,13名男性,平均年龄73.8±8.0岁),58例患者的90只眼符合纳入对照组的标准(31只眼纳入中大玻璃疣亚组,角质层玻璃疣亚组32只眼,BlamD组的27只眼.在39/40的NE-MNV患者和8/90的对照中观察到TLS。TLS诊断NE-MNV的敏感性和特异性分别为97%和91%,分别。
结论:OCT上的TLS在检测未经治疗的1型NE-MNV时显示出高灵敏度和特异性值。