Abstract：
OBJECTIVE: To assess the sensitivity and specificity of the \"triple layer sign\" (TLS) (retinal pigment epithelium (RPE), neovascular tissue, and Bruch\'s membrane) on structural optical coherence tomography (OCT) images for the diagnosis of treatment-naïve non-exudative type-1 macular neovascularization (NE-MNV) in age-related macular degeneration (AMD).
METHODS: Cross-sectional study.
METHODS: Two masked retinal experts evaluated the presence of the TLS in eyes with NE-MNV and controls with an RPE elevation without exudation due to other causes than NE-MNV in AMD [e.g., medium-large drusen, cuticular drusen, basal laminar deposits (BlamD)].
RESULTS: 130 eyes of 98 consecutive patients met the study criteria; 40 eyes of 40 patients satisfied the criteria for being included in the NE-MNV secondary to AMD group (27 females, 13 males, with a mean age of 73.8 ± 8.0 years), and 90 eyes of 58 patients met the criteria to be included in the control group (31 eyes were included in the medium-to-large drusen sub-group, 32 eyes in the cuticular drusen sub-group, and 27 eyes in the BlamD group. The TLS was observed in 39/40 patients with NE-MNV and 8/90 controls. The sensitivity and specificity of the TLS for the diagnosis of NE-MNV were 97% and 91%, respectively.
CONCLUSIONS: The TLS on OCT demonstrated high sensitivity and specificity values in detecting treatment-naive type 1 NE-MNV.
METHODS: Cross-sectional study.
METHODS: Two masked retinal experts evaluated the presence of the TLS in eyes with NE-MNV and controls with an RPE elevation without exudation due to other causes than NE-MNV in AMD [e.g., medium-large drusen, cuticular drusen, basal laminar deposits (BlamD)].
RESULTS: 130 eyes of 98 consecutive patients met the study criteria; 40 eyes of 40 patients satisfied the criteria for being included in the NE-MNV secondary to AMD group (27 females, 13 males, with a mean age of 73.8 ± 8.0 years), and 90 eyes of 58 patients met the criteria to be included in the control group (31 eyes were included in the medium-to-large drusen sub-group, 32 eyes in the cuticular drusen sub-group, and 27 eyes in the BlamD group. The TLS was observed in 39/40 patients with NE-MNV and 8/90 controls. The sensitivity and specificity of the TLS for the diagnosis of NE-MNV were 97% and 91%, respectively.
CONCLUSIONS: The TLS on OCT demonstrated high sensitivity and specificity values in detecting treatment-naive type 1 NE-MNV.
摘要：
目的：评估“三层标志”（TLS）（视网膜色素上皮（RPE），新生血管组织,和布鲁赫膜）在结构光学相干断层扫描（OCT）图像上，用于诊断年龄相关性黄斑变性（AMD）的未治疗非渗出性1型黄斑新生血管（NE-MNV）。
方法：横断面研究。
方法：两名蒙面视网膜专家评估了患有NE-MNV的眼睛和患有RPE升高的对照者中TLS的存在，而没有由于NE-MNV以外的其他原因导致的渗出[例如，中型玻璃疣,角质层玻璃疣,基底层状沉积物(BlamD)]。
结果：连续98例患者的130只眼符合研究标准；40例患者的40只眼符合纳入NE-MNV继发AMD组的标准（27例女性，13名男性，平均年龄73.8±8.0岁)，58例患者的90只眼符合纳入对照组的标准（31只眼纳入中大玻璃疣亚组，角质层玻璃疣亚组32只眼，BlamD组的27只眼.在39/40的NE-MNV患者和8/90的对照中观察到TLS。TLS诊断NE-MNV的敏感性和特异性分别为97%和91%,分别。
结论：OCT上的TLS在检测未经治疗的1型NE-MNV时显示出高灵敏度和特异性值。
方法：横断面研究。
方法：两名蒙面视网膜专家评估了患有NE-MNV的眼睛和患有RPE升高的对照者中TLS的存在，而没有由于NE-MNV以外的其他原因导致的渗出[例如，中型玻璃疣,角质层玻璃疣,基底层状沉积物(BlamD)]。
结果：连续98例患者的130只眼符合研究标准；40例患者的40只眼符合纳入NE-MNV继发AMD组的标准（27例女性，13名男性，平均年龄73.8±8.0岁)，58例患者的90只眼符合纳入对照组的标准（31只眼纳入中大玻璃疣亚组，角质层玻璃疣亚组32只眼，BlamD组的27只眼.在39/40的NE-MNV患者和8/90的对照中观察到TLS。TLS诊断NE-MNV的敏感性和特异性分别为97%和91%,分别。
结论：OCT上的TLS在检测未经治疗的1型NE-MNV时显示出高灵敏度和特异性值。
