Abstract：
Aim: This multicenter retrospective study aimed to develop a novel prognostic system for extranodal natural killer/T-cell lymphoma (ENKTL) patients in the era of pegaspargase/L-asparaginase. Materials & methods: A total of 844 newly diagnosed ENKTL patients were included. Results: Multivariable analysis confirmed that Eastern Cooperative Oncology Group performance status, lactate dehydrogenase, Chinese Southwest Oncology Group and Asia Lymphoma Study Group ENKTL (CA) system, and albumin were independent prognostic factors. By rounding up the hazard ratios from four significant variables, a maximum of 7 points were assigned. The model of Huaihai Lymphoma Working Group-Natural killer/T-cell Lymphoma prognostic index (NPI) was identified with four risk groups and the 5-year overall survival was 88.2, 66.7, 54.3 and 30.5%, respectively. Conclusion: Huaihai Lymphoma Working Group-NPI provides a feasible stratification system for patients with ENKTL in the era of pegaspargase/L-asparaginase.
[Box: see text].
[Box: see text].
摘要：
目的：这项多中心回顾性研究旨在为pegaspargase/L-天冬酰胺酶时代的结外自然杀伤/T细胞淋巴瘤（ENKTL）患者开发一种新型预后系统。材料与方法：共纳入844例新诊断的ENKTL患者。结果：多变量分析证实，东部肿瘤协作组的绩效状态，乳酸脱氢酶,中国西南肿瘤组和亚洲淋巴瘤研究组ENKTL（CA）系统，和白蛋白是独立的预后因素。通过四舍五入四个重要变量的危险比，最多分配7分。淮海淋巴瘤工作组-自然杀伤/T细胞淋巴瘤预后指数（NPI）模型确定为四个危险组，5年总生存率分别为88.2、66.7、54.3和30.5％。分别。结论：淮海淋巴瘤工作组-NPI为PEGaspargase/L-天冬酰胺酶时代的ENKTL患者提供了可行的分层系统。
[方框：见正文]。
[方框：见正文]。
