PDF(Pubmed)
Abstract：
Understanding the differences in genetic variation between local Chinese dairy goat breeds and imported breeds can help germplasm innovation and molecular breeding. However, the research is limited in this area. In this study, whole-genome resequencing data from 134 individuals of both local and imported dairy goat breeds were analyzed, and their differences in genomic genetic variation, genetic diversity, and population structure were subsequently identified. We also screened candidate genes associated with important traits of dairy goats such as milk production (STK3, GHR, PRELID3B), reproduction (ATP5E), growth and development (CTSZ, GHR), and immune function (CTSZ, NELFCD). Furthermore, we examined allele frequency distributions for the genes of interest and found significant differences between the two populations. This study provides valuable resources for the study of genetic diversity in dairy goats and lays the foundation for the selective breeding of dairy goats in the future.
摘要：
了解中国本地奶山羊品种和进口品种之间的遗传变异差异，有助于种质创新和分子育种。然而,这方面的研究是有限的。在这项研究中,分析了来自本地和进口奶山羊品种的134个个体的全基因组重测序数据，以及它们在基因组遗传变异中的差异，遗传多样性,随后确定了人口结构。我们还筛选了与奶山羊重要性状相关的候选基因，如产奶量(STK3，GHR，PRELID3B),繁殖（ATP5E），生长发育(CTSZ，GHR),和免疫功能(CTSZ，NELFCD).此外，我们检查了感兴趣基因的等位基因频率分布，发现两个群体之间存在显著差异。本研究为奶山羊遗传多样性研究提供了宝贵的资源,为今后奶山羊的选择性育种奠定了基础。
