PDF(Pubmed)
Abstract：
UNASSIGNED: The incidence of endometrial cancer is increasing, and oxidative stress has been suggested to play a vital role in its carcinogenesis. Statins have an impact on the cellular redox-state. The aim of this study was to determine the effects of statin use on redox-state regulating enzymes in endometrial cancer in women with type 2 diabetes.
UNASSIGNED: This retrospective study consisted of 119 women with type 2 diabetes who were diagnosed with endometrial cancer at Oulu University Hospital in Finland between 2007 and 2014. There were 58 statin users and 61 non-users based on medication use at the time of endometrial cancer diagnosis. The expression of redox-state regulating proteins nuclear factor erythroid 2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) in the tumor samples was assessed immunohistochemically, and manganese superoxide dismutase (MnSOD) levels were measured both immunohistochemically and from serum samples.
UNASSIGNED: High MnSOD expression predicted better progression-free survival (PFS) in statin non-users in a univariate analysis (p=0.02). There was no statistical difference in overall survival (OS) or PFS between strong and weak expression of Nrf2 and Keap1. After adjusting for stage and statin use, the results were similar.
UNASSIGNED: Statin non-users with strong MnSOD expression had better PFS compared to statin users which proves that statins have impact on redox-state regulating enzymes. However, these findings are preliminary and require further research.
UNASSIGNED: This retrospective study consisted of 119 women with type 2 diabetes who were diagnosed with endometrial cancer at Oulu University Hospital in Finland between 2007 and 2014. There were 58 statin users and 61 non-users based on medication use at the time of endometrial cancer diagnosis. The expression of redox-state regulating proteins nuclear factor erythroid 2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) in the tumor samples was assessed immunohistochemically, and manganese superoxide dismutase (MnSOD) levels were measured both immunohistochemically and from serum samples.
UNASSIGNED: High MnSOD expression predicted better progression-free survival (PFS) in statin non-users in a univariate analysis (p=0.02). There was no statistical difference in overall survival (OS) or PFS between strong and weak expression of Nrf2 and Keap1. After adjusting for stage and statin use, the results were similar.
UNASSIGNED: Statin non-users with strong MnSOD expression had better PFS compared to statin users which proves that statins have impact on redox-state regulating enzymes. However, these findings are preliminary and require further research.
摘要：
■子宫内膜癌的发病率正在增加，氧化应激在其癌变过程中起着至关重要的作用。他汀类药物对细胞氧化还原状态有影响。这项研究的目的是确定使用他汀类药物对2型糖尿病女性子宫内膜癌氧化还原状态调节酶的影响。
这项回顾性研究包括2007年至2014年在芬兰奥卢大学医院诊断为子宫内膜癌的119名2型糖尿病女性。根据子宫内膜癌诊断时的药物使用情况，有58名他汀类药物使用者和61名非使用者。免疫组织化学评估肿瘤样品中氧化还原状态调节蛋白核因子红细胞2相关因子2（Nrf2）和Kelch样ECH相关蛋白1（Keap1）的表达，通过免疫组织化学和血清样品测量锰超氧化物歧化酶（MnSOD）水平。
■在单变量分析中，高MnSOD表达预测他汀类药物非使用者的无进展生存期（PFS）更好（p=0.02）。Nrf2和Keap1的强表达和弱表达之间的总生存期（OS）或PFS没有统计学差异。在调整阶段和他汀类药物使用后，结果相似。
■与他汀类药物使用者相比，具有强MnSOD表达的他汀类药物非使用者具有更好的PFS，这证明他汀类药物对氧化还原状态调节酶有影响。然而,这些发现是初步的，需要进一步研究。
这项回顾性研究包括2007年至2014年在芬兰奥卢大学医院诊断为子宫内膜癌的119名2型糖尿病女性。根据子宫内膜癌诊断时的药物使用情况，有58名他汀类药物使用者和61名非使用者。免疫组织化学评估肿瘤样品中氧化还原状态调节蛋白核因子红细胞2相关因子2（Nrf2）和Kelch样ECH相关蛋白1（Keap1）的表达，通过免疫组织化学和血清样品测量锰超氧化物歧化酶（MnSOD）水平。
■在单变量分析中，高MnSOD表达预测他汀类药物非使用者的无进展生存期（PFS）更好（p=0.02）。Nrf2和Keap1的强表达和弱表达之间的总生存期（OS）或PFS没有统计学差异。在调整阶段和他汀类药物使用后，结果相似。
■与他汀类药物使用者相比，具有强MnSOD表达的他汀类药物非使用者具有更好的PFS，这证明他汀类药物对氧化还原状态调节酶有影响。然而,这些发现是初步的，需要进一步研究。
