PDF(Pubmed)
Abstract：
The non-natriuretic-dependent glutamate/cystine inverse transporter-system Xc- is composed of two protein subunits, SLC7A11 and SLC3A2, with SLC7A11 serving as the primary functional component responsible for cystine uptake and glutathione biosynthesis. SLC7A11 is implicated in tumor development through its regulation of redox homeostasis, amino acid metabolism, modulation of immune function, and induction of programmed cell death, among other processes relevant to tumorigenesis. In this paper, we summarize the structure and biological functions of SLC7A11, and discuss its potential role in tumor therapy, which provides a new direction for precision and personalized treatment of tumors.
摘要：
非利尿钠依赖性谷氨酸/胱氨酸反向转运系统Xc-由两个蛋白质亚基组成，SLC7A11和SLC3A2,其中SLC7A11作为负责胱氨酸摄取和谷胱甘肽生物合成的主要功能成分。SLC7A11通过调节氧化还原稳态参与肿瘤的发展，氨基酸代谢，调节免疫功能，以及细胞程序性死亡的诱导,在与肿瘤发生相关的其他过程中。在本文中,本文综述了SLC7A11的结构和生物学功能,并讨论了其在肿瘤治疗中的潜在作用,为肿瘤的精准化、个性化治疗提供了新的方向。
