Abstract：
The endocannabinoid system is composed by a complex and ubiquitous network of endogenous lipid ligands, enzymes for their synthesis and degradation, and receptors, which can also be stimulated by exogenous compounds, such as those derived from the Cannabis sativa. Cannabis and its bioactive compounds, including cannabinoids and non-cannabinoids, have been extensively studied in different conditions. Recent data have shown that the endocannabinoid system is responsible for maintaining the homeostasis of various skin functions such as proliferation, differentiation and release of inflammatory mediators. Because of their role in regulating these key processes, cannabinoids have been studied for the treatment of skin cancers and melanoma; their anti-tumour effects regulate skin cancer progression and are mainly related to the inhibition of tumour growth, proliferation, invasion and angiogenesis, through apoptosis and autophagy induction. This review aims at summarising the current field of research on the potential uses of cannabinoids in the melanoma field.
摘要：
内源性大麻素系统由内源性脂质配体的复杂和普遍存在的网络组成，酶的合成和降解，和受体，也可以被外源化合物刺激，比如那些来自大麻的。大麻及其生物活性化合物，包括大麻素和非大麻素，在不同的条件下进行了广泛的研究。最近的数据表明，内源性大麻素系统负责维持各种皮肤功能的稳态，如增殖，分化和炎症介质的释放。由于它们在调节这些关键过程中的作用，大麻素已经被研究用于治疗皮肤癌和黑色素瘤;它们的抗肿瘤作用调节皮肤癌的进展，主要与抑制肿瘤生长有关，扩散,侵袭和血管生成，通过细胞凋亡和自噬诱导。这篇综述旨在总结大麻素在黑色素瘤领域的潜在用途的当前研究领域。
