Abstract：
Dysphonia, characterized by disturbances in voice quality and modulation, has been sporadically observed in individuals with Anorexia Nervosa (AN), potentially stemming from both organic and psychopathological factors. This study seeks to employ software-based voice analysis to compare the voices of girls with AN to those of female healthy controls (HC). Case-control study adopting \"Praat\" software to assess voices. Various parameters, including Acoustic Voice Quality Index (AVQI), Fundamental Frequency (F0), Yanagihara\'s Spectrographic Dysphonia Classifications, and \"GIRBAS\" perceptual qualitative voice rating, were investigated. Participants completed questionnaires for Vocal Fatigue Index (VFI) and the Reflux Symptoms Index (RSI). Puberty-related voice spectrum changes were considered, and Bonferroni-corrected BMI-adjusted Analyses of Covariance (ANCOVAs) were conducted. The study enrolled 15 girls with AN and 23 girls with HC. AN patients demonstrated greater impairment in voice tiredness/voice avoidance (VFI-1, p < 0.001), vocal physical discomfort (VIF-2, p = 0.002), and rest as alleviation (VFI-3, p = 0.012). Reflux-related scores were higher in AN (p < 0.001). Differences were observed in voice quality (AVQI) (p = 0.001), and GIRBAS scales showed alterations in multiple parameters. Spectrograms documented more frequent pathological findings in AN patients (p = 0.021). No difference was observed in Fundamental Frequency. These group (AN/HC) differences were independent of weight measures. This study is the first to connect voice irregularities in AN by employing standardized, non-invasive tools and accounting for weight-related factors. Young AN patients demonstrated substantial voice quality changes and heightened self-reported symptoms. Future research should expand on these findings with prospective designs and invasive investigations.
摘要：
发声障碍,以语音质量和调制干扰为特征，在患有神经性厌食症(AN)的个体中偶尔观察到，可能源于有机和精神病理学因素。这项研究旨在采用基于软件的语音分析来比较患有AN的女孩与女性健康对照（HC）的声音。病例对照研究采用“Praat”软件评估声音。各种参数，包括声学语音质量指数(AVQI)，基本频率(F0),柳原光谱学发声困难分类，和“GIRBAS”感知定性语音评级，被调查了。参与者完成了声乐疲劳指数（VFI）和反流症状指数（RSI）的问卷调查。考虑了青春期相关的语音频谱变化，进行了Bonferroni校正的BMI校正协方差分析（ANCOVA）。该研究招募了15名患有AN的女孩和23名患有HC的女孩。AN患者在语音疲劳/语音回避方面表现出更大的损害（VFI-1，p<0.001），声音身体不适（VIF-2，p=0.002），休息作为缓解(VFI-3，p=0.012)。反流相关评分在AN中较高(p<0.001)。语音质量（AVQI）存在差异（p=0.001），和GIRBAS量表显示多个参数的变化。频谱图记录了AN患者更频繁的病理发现（p=0.021）。在基本频率中没有观察到差异。这些组(AN/HC)差异与体重测量无关。这项研究是第一个通过采用标准化的方法来连接AN中的语音违规行为，非侵入性工具和考虑体重相关因素。年轻的AN患者表现出实质性的语音质量变化和自我报告的症状加剧。未来的研究应该通过前瞻性设计和侵入性调查来扩展这些发现。
