PDF(Pubmed)
Abstract：
Ultrasound-based shear wave elastography (SWE) can non-invasively assess prostate tissue stiffness for the diagnosis of prostate cancer (PCa). So far, there is no widely recognized standard for the detection process and calculation method of Young\'s modulus value in transrectal SWE ultrasound imaging (TSWEUI). In our study, the mean maximum Young\'s modulus value (m-Emax) of the maximum cross-section of prostate is obtained by calculating the mean of 12 measured Emax in the four quadrants. This retrospective study included 209 suspected malignant prostate disease patients with pathological results in our hospital. Among the 209 patients, 75 patients completed TSWEUI, and 63 of the 75 patients completed magnetic resonance imaging (MRI). The area under the receiver operating characteristic (ROC) curve (AUC) of 75 patients for m-Emax was 0.754. The prostate volume, prostate-specific antigen, and m-Emax were used to develop a nomogram (AUC = 0.868). The nomogram could effectively predict the probability of PCa, thereby reducing the needle biopsy rate for diagnosing PCa. The AUC of 63 patients was not statistically different between m-Emax (AUC = 0.717) and MRI (AUC = 0.787) (P = 0.361). These indicate that m-Emax can be used as an innovative parameter in TSWEUI to diagnosis PCa. TSWEUI is more cost-effective than MRI in diagnosing PCa.
摘要：
基于超声的剪切波弹性成像(SWE)可以非侵入性地评估前列腺组织硬度以诊断前列腺癌(PCa)。到目前为止,经直肠SWE超声成像（TSWEUI）中杨氏模量值的检测过程和计算方法尚无广泛认可的标准。在我们的研究中,前列腺最大横截面的平均最大杨氏模量值(m-Emax)是通过计算四个象限中12个测量Emax的平均值获得的。这项回顾性研究包括在我院有病理结果的209例疑似恶性前列腺疾病患者。在209名患者中，75名患者完成了TSWEUI，75例患者中有63例完成了磁共振成像（MRI）。75例患者m-Emax的受试者工作特征（ROC）曲线下面积（AUC）为0.754。前列腺体积,前列腺特异性抗原,和m-Emax用于建立列线图(AUC=0.868)。列线图可以有效地预测PCa的概率，从而降低诊断PCa的穿刺活检率。m-Emax(AUC=0.717)与MRI(AUC=0.787)之间的AUC差异无统计学意义(P=0.361)。这些表明m-Emax可以作为TSWEUI诊断PCa的创新参数。在诊断PCa方面，TSWEUI比MRI更具成本效益。
