Abstract:
A previously healthy male patient presented with relapsing serous effusions affecting the pleural, pericardial and peritoneal membranes, along with thrombocytopaenia, following infection with COVID-19. An extensive workup was performed to rule out potential causes of polyserositis, including an infectious disease screen, autoantibody testing and imaging; however, no clear other cause was found. He exhibited a robust response to high-dose corticosteroid therapy but experienced several recurrences on tapering of treatment. His clinical course and treatment response were most suggestive of an autoimmune or autoinflammatory cause of polyserositis, though without confirmation of a specific underlying diagnosis. This report builds on existing literature on a possible link between COVID-19 and polyserositis.
摘要:
先前健康的男性患者出现复发性浆液性积液,影响胸膜,心包和腹膜,伴随着血小板减少症,感染COVID-19后。进行了广泛的检查以排除多发性浆膜炎的潜在原因,包括传染病筛查,自身抗体检测和成像;然而,没有找到明确的其他原因。他对高剂量皮质类固醇治疗表现出强烈的反应,但在逐渐减弱的治疗中经历了几次复发。他的临床过程和治疗反应最可能是多发性浆膜炎的自身免疫性或自身炎症性原因,尽管没有确认具体的潜在诊断。本报告建立在关于COVID-19与多发性浆膜炎之间可能联系的现有文献的基础上。