Abstract：
Chitin is a polymer of N-acetylglucosamine and an essential component of the fungal cell wall. Chitosan is the deacetylated form of chitin and is also important for maintaining the integrity of this structure. Both polysaccharides are widely distributed in nature and have been shown to have a variety of applications in biomedicine, including their potential in immune sensing and as potential antifungal agents. In addition, chitin has been reported to play an important role in the pathogen-host interaction, involving innate and adaptive immune responses. This paper will explore the role of chitin and chitosan when incorporated into nanobiocomposites to improve their efficacy in detecting fungi of medical interest and inhibiting their growth. Potential applications in diagnostic and therapeutic medicine will be discussed, highlighting their promise in the development of more sensitive and effective tools for the early diagnosis of fungal infections. This review aims to highlight the importance of the convergence of nanotechnology and biology in addressing public health challenges.
摘要：
几丁质是N-乙酰葡糖胺的聚合物，是真菌细胞壁的必需成分。壳聚糖是几丁质的脱乙酰化形式,并且对于保持该结构的完整性也是重要的。这两种多糖在自然界中分布广泛,在生物医学中具有多种应用,包括它们在免疫传感和潜在抗真菌药物方面的潜力。此外,据报道，几丁质在病原体-宿主相互作用中起重要作用，涉及先天和适应性免疫反应。本文将探讨几丁质和壳聚糖掺入纳米生物复合材料中的作用，以提高其在检测医学意义的真菌和抑制其生长方面的功效。将讨论在诊断和治疗医学中的潜在应用，强调他们在开发更敏感和有效的真菌感染早期诊断工具方面的承诺。这篇综述旨在强调纳米技术和生物学融合在应对公共卫生挑战方面的重要性。
