Abstract：
OBJECTIVE: This study aims to conduct an extensive analysis of autoimmune bullous diseases, particularly pemphigus vulgaris and bullous pemphigoid, in Shanghai, China, from 2016 to 2023. It seeks to understand the demographic profiles, comorbidities, mortality rates, risk factors, and socioeconomic impacts associated with autoimmune bullous disease.
METHODS: A cross-sectional study design was employed, enrolling 1,072 patients. Diagnostic measures included clinical manifestations, histopathology, direct immunofluorescence, and serologic tests. The study also involved a detailed socioeconomic analysis and evaluation of occupational risks.
RESULTS: The findings highlight a significant occupational risk in industries requiring enhanced safety measures, with a notable prevalence of autoimmune bullous disease among workers in these sectors. A considerable portion of the patients were from low-income backgrounds with limited literacy, indicating the economic burden of autoimmune bullous disease. A key discovery of the study is the potential pathological link between autoimmune bullous disease and interstitial lung disease.
CONCLUSIONS: This research, one of the first comprehensive studies on autoimmune bullous disease in China, underscores the need for targeted healthcare strategies and further investigation into autoimmune bullous disease, particularly its relationship with interstitial lung disease.
METHODS: A cross-sectional study design was employed, enrolling 1,072 patients. Diagnostic measures included clinical manifestations, histopathology, direct immunofluorescence, and serologic tests. The study also involved a detailed socioeconomic analysis and evaluation of occupational risks.
RESULTS: The findings highlight a significant occupational risk in industries requiring enhanced safety measures, with a notable prevalence of autoimmune bullous disease among workers in these sectors. A considerable portion of the patients were from low-income backgrounds with limited literacy, indicating the economic burden of autoimmune bullous disease. A key discovery of the study is the potential pathological link between autoimmune bullous disease and interstitial lung disease.
CONCLUSIONS: This research, one of the first comprehensive studies on autoimmune bullous disease in China, underscores the need for targeted healthcare strategies and further investigation into autoimmune bullous disease, particularly its relationship with interstitial lung disease.
摘要：
目的：本研究旨在对自身免疫性大疱性疾病进行广泛分析，特别是寻常型天疱疮和大疱性类天疱疮，在上海,中国,从2016年到2023年。它试图了解人口概况，合并症,死亡率,危险因素，以及与自身免疫性大疱性疾病相关的社会经济影响。
方法：采用横断面研究设计，招募1072名患者。诊断措施包括临床表现，组织病理学,直接免疫荧光，和血清学测试。该研究还涉及对职业风险的详细社会经济分析和评估。
结果：调查结果强调了需要加强安全措施的行业中的重大职业风险，在这些部门的工人中，自身免疫性大疱性疾病的患病率显着。相当一部分患者来自低收入背景，识字能力有限，表明自身免疫性大疱性疾病的经济负担。这项研究的一个关键发现是自身免疫性大疱性疾病和间质性肺病之间的潜在病理联系。
结论：这项研究，中国最早的自身免疫性大疱性疾病综合研究之一，强调需要有针对性的医疗保健策略和进一步调查自身免疫性大疱性疾病，尤其是与间质性肺病的关系。
方法：采用横断面研究设计，招募1072名患者。诊断措施包括临床表现，组织病理学,直接免疫荧光，和血清学测试。该研究还涉及对职业风险的详细社会经济分析和评估。
结果：调查结果强调了需要加强安全措施的行业中的重大职业风险，在这些部门的工人中，自身免疫性大疱性疾病的患病率显着。相当一部分患者来自低收入背景，识字能力有限，表明自身免疫性大疱性疾病的经济负担。这项研究的一个关键发现是自身免疫性大疱性疾病和间质性肺病之间的潜在病理联系。
结论：这项研究，中国最早的自身免疫性大疱性疾病综合研究之一，强调需要有针对性的医疗保健策略和进一步调查自身免疫性大疱性疾病，尤其是与间质性肺病的关系。
