PDF(Pubmed)
Abstract：
OBJECTIVE: Many synthetic endocrine-disrupting chemicals (EDCs) are ubiquitous in the environment and highly detected among pregnant people. These chemicals may disrupt maternal and/or fetal sex steroid hormones, which are critical to pregnancy maintenance and fetal development. Here, we review the epidemiological literature examining prenatal exposure to common synthetic EDCs in relation to maternal and fetal sex steroid hormones.
RESULTS: We performed a literature search using PubMed, SCOPUS, and Embase, ultimately identifying 29 articles for full review. Phenols, parabens, and persistent organic pollutants generally showed inverse associations with androgens, estrogens, and progesterone. Phthalates and per-and polyfluoroalkyl substances tended to be inversely associated with progesterone, while evidence regarding androgens and estrogens was mixed. Inconsistent, but noteworthy, differences by fetal sex and timing of exposure/outcome were observed. Overall, the literature suggests EDCs may disrupt maternal and fetal sex steroid activity, though findings are mixed. Given the pervasive, high-volume production of these synthetic chemicals and the critical functions sex steroid hormones play during gestation, additional research is warranted.
RESULTS: We performed a literature search using PubMed, SCOPUS, and Embase, ultimately identifying 29 articles for full review. Phenols, parabens, and persistent organic pollutants generally showed inverse associations with androgens, estrogens, and progesterone. Phthalates and per-and polyfluoroalkyl substances tended to be inversely associated with progesterone, while evidence regarding androgens and estrogens was mixed. Inconsistent, but noteworthy, differences by fetal sex and timing of exposure/outcome were observed. Overall, the literature suggests EDCs may disrupt maternal and fetal sex steroid activity, though findings are mixed. Given the pervasive, high-volume production of these synthetic chemicals and the critical functions sex steroid hormones play during gestation, additional research is warranted.
摘要：
目的：许多合成的内分泌干扰化学物质（EDCs）在环境中普遍存在，并且在孕妇中被高度检测到。这些化学物质可能会破坏母体和/或胎儿的性类固醇激素，这对维持妊娠和胎儿发育至关重要。这里,我们回顾了流行病学文献，研究了产前暴露于与母体和胎儿性类固醇激素相关的常见合成EDC。
结果：我们使用PubMed进行了文献检索，Scopus,和Embase,最终确定29篇文章进行全面审查。酚类,对羟基苯甲酸酯,持久性有机污染物通常与雄激素呈负相关，雌激素,和黄体酮。邻苯二甲酸酯和过氟烷基和多氟烷基物质倾向于与孕酮呈负相关，而关于雄激素和雌激素的证据是混合的。不一致,但值得注意的是，观察到胎儿性别和暴露时间/结局的差异.总的来说,文献表明，EDC可能会破坏母体和胎儿的性类固醇活性，虽然调查结果好坏参半。鉴于无处不在，这些合成化学物质的大量生产以及性激素在妊娠期间发挥的关键功能，额外的研究是必要的。
结果：我们使用PubMed进行了文献检索，Scopus,和Embase,最终确定29篇文章进行全面审查。酚类,对羟基苯甲酸酯,持久性有机污染物通常与雄激素呈负相关，雌激素,和黄体酮。邻苯二甲酸酯和过氟烷基和多氟烷基物质倾向于与孕酮呈负相关，而关于雄激素和雌激素的证据是混合的。不一致,但值得注意的是，观察到胎儿性别和暴露时间/结局的差异.总的来说,文献表明，EDC可能会破坏母体和胎儿的性类固醇活性，虽然调查结果好坏参半。鉴于无处不在，这些合成化学物质的大量生产以及性激素在妊娠期间发挥的关键功能，额外的研究是必要的。
